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The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
J Biol Chem. 2019 Apr 5;294(14):5246-5260. doi: 10.1074/jbc.RA118.006597. Epub 2019 Feb 8.
J Biol Chem. 2019.
PMID: 30737284
Free PMC article.
Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.
Patwardhan CA, Fauq A, Peterson LB, Miller C, Blagg BS, Chadli A.
Patwardhan CA, et al.
J Biol Chem. 2013 Mar 8;288(10):7313-25. doi: 10.1074/jbc.M112.427328. Epub 2013 Jan 25.
J Biol Chem. 2013.
PMID: 23355466
Free PMC article.
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The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.
Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB.
Paul A, et al.
J Biol Chem. 2014 May 30;289(22):15297-308. doi: 10.1074/jbc.M113.535229. Epub 2014 Apr 21.
J Biol Chem. 2014.
PMID: 24753260
Free PMC article.
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Progesterone receptor chaperone complex-based high-throughput screening assay: identification of capsaicin as an inhibitor of the Hsp90 machine.
Patwardhan CA, Alfa E, Lu S, Chadli A.
Patwardhan CA, et al.
J Biomol Screen. 2015 Feb;20(2):223-9. doi: 10.1177/1087057114549147. Epub 2014 Sep 2.
J Biomol Screen. 2015.
PMID: 25184514
Free PMC article.
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Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin).
Patwardhan CA, Kommalapati VK, Llbiyi T, Singh D, Alfa E, Horuzsko A, Korkaya H, Panda S, Reilly CA, Popik V, Chadli A.
Patwardhan CA, et al.
Sci Rep. 2023 Aug 23;13(1):13790. doi: 10.1038/s41598-023-40933-9.
Sci Rep. 2023.
PMID: 37612326
Free PMC article.
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