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Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved cis-platin.
Haghdoost M, Golbaghi G, Létourneau M, Patten SA, Castonguay A. Haghdoost M, et al. Among authors: patten sa. Eur J Med Chem. 2017 May 26;132:282-293. doi: 10.1016/j.ejmech.2017.03.029. Epub 2017 Mar 18. Eur J Med Chem. 2017. PMID: 28371640
Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos.
Golbaghi G, Haghdoost MM, Yancu D, Santos YLL, Doucet N, Patten SA, Sanderson JT, Castonguay A. Golbaghi G, et al. Among authors: patten sa. Organometallics. 2019 Feb 11;38(3):702-711. doi: 10.1021/acs.organomet.8b00897. Epub 2019 Jan 31. Organometallics. 2019. PMID: 31762529 Free PMC article.
BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation.
Silva MJSA, Zhang Y, Vinck R, Santos FMF, António JPM, Gourdon-Grünewaldt L, Zaouter C, Castonguay A, Patten SA, Cariou K, Boscá F, Nájera F, Arteaga JF, Gasser G, Pischel U, Gois PMP. Silva MJSA, et al. Among authors: patten sa. Bioconjug Chem. 2023 Dec 20;34(12):2337-2344. doi: 10.1021/acs.bioconjchem.3c00449. Epub 2023 Nov 10. Bioconjug Chem. 2023. PMID: 37948301
Design and biological assessment of membrane-tethering neuroprotective peptides derived from the pituitary adenylate cyclase-activating polypeptide type 1 receptor.
Poujol de Molliens M, Jamadagni P, Létourneau M, Devost D, Hébert TE, Patten SA, Fournier A, Chatenet D. Poujol de Molliens M, et al. Among authors: patten sa. Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129398. doi: 10.1016/j.bbagen.2019.07.007. Epub 2019 Jul 12. Biochim Biophys Acta Gen Subj. 2019. PMID: 31306709
45 results