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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: paterno jj. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
Inflammation and its role in age-related macular degeneration.
Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Kauppinen A, et al. Among authors: paterno jj. Cell Mol Life Sci. 2016 May;73(9):1765-86. doi: 10.1007/s00018-016-2147-8. Epub 2016 Feb 6. Cell Mol Life Sci. 2016. PMID: 26852158 Free PMC article. Review.
Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a Independent of C3.
Sridevi Gurubaran I, Heloterä H, Marry S, Koskela A, Hyttinen JMT, Paterno JJ, Urtti A, Chen M, Xu H, Kauppinen A, Kaarniranta K. Sridevi Gurubaran I, et al. Among authors: paterno jj. Biology (Basel). 2021 Jul 4;10(7):622. doi: 10.3390/biology10070622. Biology (Basel). 2021. PMID: 34356477 Free PMC article.
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice.
Tamminen T, Koskela A, Toropainen E, Gurubaran IS, Winiarczyk M, Liukkonen M, Paterno JJ, Lackman P, Sadeghi A, Viiri J, Hyttinen JMT, Koskelainen A, Kaarniranta K. Tamminen T, et al. Among authors: paterno jj. Oxid Med Cell Longev. 2021 Dec 7;2021:8028427. doi: 10.1155/2021/8028427. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34917233 Free PMC article. Retracted.
16 results