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Tofacitinib to prevent anti-drug antibody formation against LMB-100 immunotoxin in patients with advanced mesothelin-expressing cancers.
Skorupan N, Peer CJ, Zhang X, Choo-Wosoba H, Ahmad MI, Lee MJ, Rastogi S, Sato N, Yu Y, Pegna GJ, Steinberg SM, Kalsi SS, Cao L, Figg WD, Trepel JB, Pastan I, FitzGerald D, Alewine C. Skorupan N, et al. Among authors: pastan i. Front Oncol. 2024 Apr 19;14:1386190. doi: 10.3389/fonc.2024.1386190. eCollection 2024. Front Oncol. 2024. PMID: 38706610 Free PMC article.
Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D. Zhan J, et al. Among authors: pastan i. Cancer Res Commun. 2023 Feb 1;3(2):175-191. doi: 10.1158/2767-9764.CRC-22-0306. eCollection 2023 Feb. Cancer Res Commun. 2023. PMID: 36968141 Free PMC article.
A tri-specific killer engager against mesothelin targets NK cells towards lung cancer.
Kennedy PR, Vallera DA, Ettestad B, Hallstrom C, Kodal B, Todhunter DA, Bendzick L, Hinderlie P, Walker JT, Pulkrabek B, Pastan I, Kratzke RA, Fujioka N, Miller JS, Felices M. Kennedy PR, et al. Among authors: pastan i. Front Immunol. 2023 Feb 22;14:1060905. doi: 10.3389/fimmu.2023.1060905. eCollection 2023. Front Immunol. 2023. PMID: 36911670 Free PMC article.
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.
Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon JE 2nd, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Parker S, et al. Among authors: pastan ih. Sci Transl Med. 2023 Feb 8;15(682):eabn5649. doi: 10.1126/scitranslmed.abn5649. Epub 2023 Feb 8. Sci Transl Med. 2023. PMID: 36753564 Free PMC article.
Podocytes are lost from glomeruli before completing apoptosis.
Yamamoto K, Okabe M, Tanaka K, Yokoo T, Pastan I, Araoka T, Osafune K, Udagawa T, Koizumi M, Matsusaka T. Yamamoto K, et al. Among authors: pastan i. Am J Physiol Renal Physiol. 2022 Nov 1;323(5):F515-F526. doi: 10.1152/ajprenal.00080.2022. Epub 2022 Sep 1. Am J Physiol Renal Physiol. 2022. PMID: 36049065 Free PMC article.
1,281 results