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Page 1
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia.
Houshmand M, Vitale N, Orso F, Cignetti A, Molineris I, Gaidano V, Sainas S, Giorgis M, Boschi D, Fava C, Passoni A, Gai M, Geuna M, Sora F, Iurlo A, Abruzzese E, Breccia M, Mulas O, Caocci G, Castagnetti F, Taverna D, Oliviero S, Pane F, Lolli ML, Circosta P, Saglio G. Houshmand M, et al. Among authors: passoni a. Cell Death Dis. 2022 Jun 30;13(6):576. doi: 10.1038/s41419-022-05028-9. Cell Death Dis. 2022. PMID: 35773274 Free PMC article.
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
Sainas S, Temperini P, Farnsworth JC, Yi F, Møllerud S, Jensen AA, Nielsen B, Passoni A, Kastrup JS, Hansen KB, Boschi D, Pickering DS, Clausen RP, Lolli ML. Sainas S, et al. Among authors: passoni a. J Med Chem. 2019 May 9;62(9):4467-4482. doi: 10.1021/acs.jmedchem.8b01986. Epub 2019 Apr 18. J Med Chem. 2019. PMID: 30943028 Free PMC article.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety.
Sainas S, Giorgis M, Circosta P, Gaidano V, Bonanni D, Pippione AC, Bagnati R, Passoni A, Qiu Y, Cojocaru CF, Canepa B, Bona A, Rolando B, Mishina M, Ramondetti C, Buccinnà B, Piccinini M, Houshmand M, Cignetti A, Giraudo E, Al-Karadaghi S, Boschi D, Saglio G, Lolli ML. Sainas S, et al. Among authors: passoni a. J Med Chem. 2021 May 13;64(9):5404-5428. doi: 10.1021/acs.jmedchem.0c01549. Epub 2021 Apr 12. J Med Chem. 2021. PMID: 33844533 Free PMC article.
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety.
Sainas S, Giorgis M, Circosta P, Poli G, Alberti M, Passoni A, Gaidano V, Pippione AC, Vitale N, Bonanni D, Rolando B, Cignetti A, Ramondetti C, Lanno A, Ferraris DM, Canepa B, Buccinnà B, Piccinini M, Rizzi M, Saglio G, Al-Karadaghi S, Boschi D, Miggiano R, Tuccinardi T, Lolli ML. Sainas S, et al. Among authors: passoni a. J Med Chem. 2022 Oct 13;65(19):12701-12724. doi: 10.1021/acs.jmedchem.2c00496. Epub 2022 Sep 26. J Med Chem. 2022. PMID: 36162075 Free PMC article.
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
Pippione AC, Kovachka S, Vigato C, Bertarini L, Mannella I, Sainas S, Rolando B, Denasio E, Piercy-Mycock H, Romalho L, Salladini E, Adinolfi S, Zonari D, Peraldo-Neia C, Chiorino G, Passoni A, Mirza OA, Frydenvang K, Pors K, Lolli ML, Spyrakis F, Oliaro-Bosso S, Boschi D. Pippione AC, et al. Among authors: passoni a. Eur J Med Chem. 2024 Mar 15;268:116193. doi: 10.1016/j.ejmech.2024.116193. Epub 2024 Feb 7. Eur J Med Chem. 2024. PMID: 38364714 Free article.
Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.
Regoni M, Cattaneo S, Mercatelli D, Novello S, Passoni A, Bagnati R, Davoli E, Croci L, Consalez GG, Albanese F, Zanetti L, Passafaro M, Serratto GM, Di Fonzo A, Valtorta F, Ciammola A, Taverna S, Morari M, Sassone J. Regoni M, et al. Among authors: passoni a. Cell Death Dis. 2020 Nov 10;11(11):963. doi: 10.1038/s41419-020-03172-8. Cell Death Dis. 2020. PMID: 33173027 Free PMC article.
Brain Disposition of cis-para-Methyl-4-Methylaminorex (cis-4,4'-DMAR) and Its Potential Metabolites after Acute and Chronic Treatment in Rats: Correlation with Central Behavioral Effects.
Lucchetti J, Marzo CM, Passoni A, Di Clemente A, Moro F, Bagnati R, Gobbi M, Cervo L. Lucchetti J, et al. Among authors: passoni a. J Pharmacol Exp Ther. 2017 Jun;361(3):492-500. doi: 10.1124/jpet.117.240788. Epub 2017 Apr 12. J Pharmacol Exp Ther. 2017. PMID: 28404688
54 results