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Design, synthesis and structure-activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate.
Ratcliffe P, Adam JM, Baker J, Bursi R, Campbell R, Clark JK, Cottney JE, Deehan M, Easson AM, Ecker D, Edwards D, Epemolu O, Evans L, Fields R, Francis S, Harradine P, Jeremiah F, Kiyoi T, McArthur D, Morrison A, Passier P, Pick J, Schnabel PG, Schulz J, Steinbrede H, Walker G, Westwood P, Wishart G, Udo de Haes J. Ratcliffe P, et al. Among authors: passier p. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2541-6. doi: 10.1016/j.bmcl.2011.02.023. Epub 2011 Feb 12. Bioorg Med Chem Lett. 2011. PMID: 21411321
Sugammadex is cleared rapidly and primarily unchanged via renal excretion.
Peeters P, Passier P, Smeets J, Zwiers A, de Zwart M, van de Wetering-Krebbers S, van Iersel M, van Marle S, van den Dobbelsteen D. Peeters P, et al. Among authors: passier p. Biopharm Drug Dispos. 2011 Apr;32(3):159-67. doi: 10.1002/bdd.747. Epub 2011 Mar 1. Biopharm Drug Dispos. 2011. PMID: 21370235
Translational PK-PD modeling in pain.
Yassen A, Passier P, Furuichi Y, Dahan A. Yassen A, et al. Among authors: passier p. J Pharmacokinet Pharmacodyn. 2013 Jun;40(3):401-18. doi: 10.1007/s10928-012-9282-0. Epub 2012 Nov 30. J Pharmacokinet Pharmacodyn. 2013. PMID: 23197248 Review.
The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation.
Rittig S, Baka-Ostrowska M, Tøndel C, Walle JV, Kjaeer B, Passier P, Bosman B, Stroosma O, Tannenbaum S. Rittig S, et al. Among authors: passier p. J Pediatr Urol. 2020 Feb;16(1):31.e1-31.e10. doi: 10.1016/j.jpurol.2019.10.009. Epub 2019 Oct 22. J Pediatr Urol. 2020. PMID: 31787582 Free article.
39 results