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The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.
Winkler A, Sun W, De S, Jiao A, Sharif MN, Symanowicz PT, Athale S, Shin JH, Wang J, Jacobson BA, Ramsey SJ, Dower K, Andreyeva T, Liu H, Hegen M, Homer BL, Brodfuehrer J, Tilley M, Gilbert SA, Danto SI, Beebe JJ, Barnes BJ, Pascual V, Lin LL, Kilty I, Fleming M, Rao VR. Winkler A, et al. Among authors: pascual v. Arthritis Rheumatol. 2021 Dec;73(12):2206-2218. doi: 10.1002/art.41953. Epub 2021 Nov 1. Arthritis Rheumatol. 2021. PMID: 34423919 Free PMC article. Clinical Trial.
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab.
Grom AA, Ilowite NT, Pascual V, Brunner HI, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group; Leon K, Lheritier K, Abrams K. Grom AA, et al. Among authors: pascual v. Arthritis Rheumatol. 2016 Jan;68(1):218-28. doi: 10.1002/art.39407. Arthritis Rheumatol. 2016. PMID: 26314396
A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.
Caielli S, Veiga DT, Balasubramanian P, Athale S, Domic B, Murat E, Banchereau R, Xu Z, Chandra M, Chung CH, Walters L, Baisch J, Wright T, Punaro M, Nassi L, Stewart K, Fuller J, Ucar D, Ueno H, Zhou J, Banchereau J, Pascual V. Caielli S, et al. Among authors: pascual v. Nat Med. 2019 Jan;25(1):75-81. doi: 10.1038/s41591-018-0254-9. Epub 2018 Nov 26. Nat Med. 2019. PMID: 30478422 Free PMC article.
Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers.
Gofshteyn JS, Mansfield L, Spitznagle J, Balasubramanian P, Cardenas J, Miller T, Gu J, Wang X, Punaro M, Fuller J, Nassi L, Stewart K, Ohouo M, Stagnar C, Baisch J, Walters L, Wang Y, Yan H, Rinchai D, Chaussabel D, Caielli S, Hong S, Onel K, Wright T, Pascual V. Gofshteyn JS, et al. Among authors: pascual v. Arthritis Rheumatol. 2023 Jul;75(7):1246-1261. doi: 10.1002/art.42446. Epub 2023 May 18. Arthritis Rheumatol. 2023. PMID: 36648920
265 results