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mRNAid, an open-source platform for therapeutic mRNA design and optimization strategies.
Vostrosablin N, Lim S, Gopal P, Brazdilova K, Parajuli S, Wei X, Gromek A, Prihoda D, Spale M, Muzdalo A, Greig J, Yeo C, Wardyn J, Mejzlik P, Henry B, Partridge AW, Bitton DA. Vostrosablin N, et al. Among authors: partridge aw. NAR Genom Bioinform. 2024 Mar 12;6(1):lqae028. doi: 10.1093/nargab/lqae028. eCollection 2024 Mar. NAR Genom Bioinform. 2024. PMID: 38482061 Free PMC article.
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development.
Wirjanata G, Lin J, Dziekan JM, El Sahili A, Chung Z, Tjia S, Binte Zulkifli NE, Boentoro J, Tham R, Jia LS, Go KD, Yu H, Partridge A, Olsen D, Prabhu N, Sobota RM, Nordlund P, Lescar J, Bozdech Z. Wirjanata G, et al. Cell Chem Biol. 2024 Apr 18;31(4):743-759.e8. doi: 10.1016/j.chembiol.2024.03.002. Epub 2024 Apr 8. Cell Chem Biol. 2024. PMID: 38593807
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Chandramohan A, Josien H, Yuen TY, Duggal R, Spiegelberg D, Yan L, Juang YA, Ge L, Aronica PG, Kaan HYK, Lim YH, Peier A, Sherborne B, Hochman J, Lin S, Biswas K, Nestor M, Verma CS, Lane DP, Sawyer TK, Garbaccio R, Henry B, Kannan S, Brown CJ, Johannes CW, Partridge AW. Chandramohan A, et al. Among authors: partridge aw. Nat Commun. 2024 Jan 12;15(1):489. doi: 10.1038/s41467-023-43346-4. Nat Commun. 2024. PMID: 38216578 Free PMC article.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.
Kasper SH, Otten S, Squadroni B, Orr-Terry C, Kuang Y, Mussallem L, Ge L, Yan L, Kannan S, Verma CS, Brown CJ, Johannes CW, Lane DP, Chandramohan A, Partridge AW, Roberts LR, Josien H, Therien AG, Hett EC, Howell BJ, Peier A, Ai X, Cassaday J. Kasper SH, et al. Among authors: partridge aw. Bioeng Transl Med. 2023 May 13;8(5):e10542. doi: 10.1002/btm2.10542. eCollection 2023 Sep. Bioeng Transl Med. 2023. PMID: 37693049 Free PMC article.
STUB1 is an intracellular checkpoint for interferon gamma sensing.
Ng S, Lim S, Sim ACN, Mangadu R, Lau A, Zhang C, Martinez SB, Chandramohan A, Lim UM, Ho SSW, Chang SC, Gopal P, Hong LZ, Schwaid A, Fernandis AZ, Loboda A, Li C, Phan U, Henry B, Partridge AW. Ng S, et al. Among authors: partridge aw. Sci Rep. 2022 Aug 18;12(1):14087. doi: 10.1038/s41598-022-18404-4. Sci Rep. 2022. PMID: 35982220 Free PMC article.
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S, Sadruddin A, Yeo C, Strickland C, Peier A, Henry B, Sherer EC, Partridge AW. Ng S, et al. Among authors: partridge aw. J Med Chem. 2022 Jul 19. doi: 10.1021/acs.jmedchem.2c00406. Online ahead of print. J Med Chem. 2022. PMID: 35853179
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Lim S, Boyer N, Boo N, Huang C, Venkatachalam G, Angela Juang YC, Garrigou M, Kaan HYK, Duggal R, Peh KM, Sadruddin A, Gopal P, Yuen TY, Ng S, Kannan S, Brown CJ, Verma CS, Orth P, Peier A, Ge L, Yu X, Bhatt B, Chen F, Wang E, Li NJ, Gonzales RJ, Stoeck A, Henry B, Sawyer TK, Lane DP, Johannes CW, Biswas K, Partridge AW. Lim S, et al. Among authors: partridge aw. Chem Sci. 2021 Nov 25;12(48):15975-15987. doi: 10.1039/d1sc05187c. eCollection 2021 Dec 15. Chem Sci. 2021. PMID: 35024121 Free PMC article.
42 results