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STUB1 is an intracellular checkpoint for interferon gamma sensing.
Ng S, Lim S, Sim ACN, Mangadu R, Lau A, Zhang C, Martinez SB, Chandramohan A, Lim UM, Ho SSW, Chang SC, Gopal P, Hong LZ, Schwaid A, Fernandis AZ, Loboda A, Li C, Phan U, Henry B, Partridge AW. Ng S, et al. Among authors: partridge aw. Sci Rep. 2022 Aug 18;12(1):14087. doi: 10.1038/s41598-022-18404-4. Sci Rep. 2022. PMID: 35982220 Free PMC article.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, Surdi L, Peier A, Sauvagnat B, Dandliker PJ, Brown CJ, Ng S, Ferrer F, Lane DP. Sawyer TK, et al. Among authors: partridge aw. Bioorg Med Chem. 2018 Jun 1;26(10):2807-2815. doi: 10.1016/j.bmc.2018.03.008. Epub 2018 Mar 16. Bioorg Med Chem. 2018. PMID: 29598901
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).
Lim S, Khoo R, Peh KM, Teo J, Chang SC, Ng S, Beilhartz GL, Melnyk RA, Johannes CW, Brown CJ, Lane DP, Henry B, Partridge AW. Lim S, et al. Among authors: partridge aw. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5791-5800. doi: 10.1073/pnas.1920251117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123106 Free PMC article.
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, Arumugam P, Han Y, Chen S, Rénia L, Brown CJ, Johannes CW, Henry B, Lane DP, Sawyer TK, Verma CS, Partridge AW. Kannan S, et al. Among authors: partridge aw. Chem Sci. 2020 May 11;11(21):5577-5591. doi: 10.1039/c9sc06383h. eCollection 2020 Jun 7. Chem Sci. 2020. PMID: 32874502 Free PMC article.
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.
Ng S, Juang YC, Chandramohan A, Kaan HYK, Sadruddin A, Yuen TY, Ferrer-Gago FJ, Lee XC, Liew X, Johannes CW, Brown CJ, Kannan S, Aronica PG, Berglund NA, Verma CS, Liu L, Stoeck A, Sawyer TK, Partridge AW, Lane DP. Ng S, et al. Among authors: partridge aw. ACS Med Chem Lett. 2020 May 1;11(10):1993-2001. doi: 10.1021/acsmedchemlett.0c00022. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062184 Free PMC article.
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Lim S, Boyer N, Boo N, Huang C, Venkatachalam G, Angela Juang YC, Garrigou M, Kaan HYK, Duggal R, Peh KM, Sadruddin A, Gopal P, Yuen TY, Ng S, Kannan S, Brown CJ, Verma CS, Orth P, Peier A, Ge L, Yu X, Bhatt B, Chen F, Wang E, Li NJ, Gonzales RJ, Stoeck A, Henry B, Sawyer TK, Lane DP, Johannes CW, Biswas K, Partridge AW. Lim S, et al. Among authors: partridge aw. Chem Sci. 2021 Nov 25;12(48):15975-15987. doi: 10.1039/d1sc05187c. eCollection 2021 Dec 15. Chem Sci. 2021. PMID: 35024121 Free PMC article.
Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.
Ng S, Brueckner AC, Bahmanjah S, Deng Q, Johnston JM, Ge L, Duggal R, Habulihaz B, Barlock B, Ha S, Sadruddin A, Yeo C, Strickland C, Peier A, Henry B, Sherer EC, Partridge AW. Ng S, et al. Among authors: partridge aw. J Med Chem. 2022 Jul 19. doi: 10.1021/acs.jmedchem.2c00406. Online ahead of print. J Med Chem. 2022. PMID: 35853179
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Chandramohan A, Josien H, Yuen TY, Duggal R, Spiegelberg D, Yan L, Juang YA, Ge L, Aronica PG, Kaan HYK, Lim YH, Peier A, Sherborne B, Hochman J, Lin S, Biswas K, Nestor M, Verma CS, Lane DP, Sawyer TK, Garbaccio R, Henry B, Kannan S, Brown CJ, Johannes CW, Partridge AW. Chandramohan A, et al. Among authors: partridge aw. Nat Commun. 2024 Jan 12;15(1):489. doi: 10.1038/s41467-023-43346-4. Nat Commun. 2024. PMID: 38216578 Free PMC article.
46 results