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The eggstraordinary story of how life begins.
Parrington J, Arnoult C, Fissore RA. Parrington J, et al. Mol Reprod Dev. 2019 Jan;86(1):4-19. doi: 10.1002/mrd.23083. Epub 2018 Nov 30. Mol Reprod Dev. 2019. PMID: 30411426 Free PMC article. Review.
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
Kashir J, Jones C, Lee HC, Rietdorf K, Nikiforaki D, Durrans C, Ruas M, Tee ST, Heindryckx B, Galione A, De Sutter P, Fissore RA, Parrington J, Coward K. Kashir J, et al. Among authors: parrington j. Hum Reprod. 2011 Dec;26(12):3372-87. doi: 10.1093/humrep/der336. Epub 2011 Oct 18. Hum Reprod. 2011. PMID: 22010140 Free PMC article.
PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence.
Hachem A, Godwin J, Ruas M, Lee HC, Ferrer Buitrago M, Ardestani G, Bassett A, Fox S, Navarrete F, de Sutter P, Heindryckx B, Fissore R, Parrington J. Hachem A, et al. Among authors: parrington j. Development. 2017 Aug 15;144(16):2914-2924. doi: 10.1242/dev.150227. Epub 2017 Jul 10. Development. 2017. PMID: 28694258 Free PMC article.
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
Heytens E, Parrington J, Coward K, Young C, Lambrecht S, Yoon SY, Fissore RA, Hamer R, Deane CM, Ruas M, Grasa P, Soleimani R, Cuvelier CA, Gerris J, Dhont M, Deforce D, Leybaert L, De Sutter P. Heytens E, et al. Among authors: parrington j. Hum Reprod. 2009 Oct;24(10):2417-28. doi: 10.1093/humrep/dep207. Epub 2009 Jul 7. Hum Reprod. 2009. PMID: 19584136
150 results