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Combined treatment with anti-HER2/neu and anti-4-1BB monoclonal antibodies induces a synergistic antitumor effect but requires dose optimization to maintain immune memory for protection from lethal rechallenge.
Kim HY, Choi JH, Haque MM, Park JH, Kim IH, Choi BK, Lee A, Park S. Kim HY, et al. Among authors: park jh, park s. Cancer Immunol Immunother. 2022 Apr;71(4):967-978. doi: 10.1007/s00262-021-03120-1. Epub 2022 Jan 6. Cancer Immunol Immunother. 2022. PMID: 34988585 Free PMC article.
Intratumoral heterogeneity impacts the response to anti-neu antibody therapy.
Song H, Kim TO, Ma SY, Park JH, Choi JH, Kim JH, Kang MS, Bae SK, Kim KH, Kim TH, Seo SK, Choi IW, Song GA, Mortenson ED, Fu YX, Park S. Song H, et al. Among authors: park jh, park s. BMC Cancer. 2014 Sep 1;14:647. doi: 10.1186/1471-2407-14-647. BMC Cancer. 2014. PMID: 25179116 Free PMC article.
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