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Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition.
Zhu Q, Mishra A, Park JS, Liu D, Le DT, Gonzalez SZ, Anderson-Crannage M, Park JM, Park GH, Tarbay L, Daneshvar K, Brandenburg M, Signoretti C, Zinski A, Gardner EJ, Zheng KL, Abani CP, Hu C, Beaudreault CP, Zhang XL, Stanton PK, Cho JH, Velíšek L, Velíšková J, Javed S, Leonard CS, Kim HY, Chung S. Zhu Q, et al. Among authors: park gh, park js, park jm. Neuron. 2023 Mar 15;111(6):807-823.e7. doi: 10.1016/j.neuron.2022.12.014. Epub 2023 Jan 9. Neuron. 2023. PMID: 36626901 Free PMC article.
Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells.
Ni P, Noh H, Shao Z, Zhu Q, Guan Y, Park JJ, Arif F, Park JM, Abani C, Beaudreault C, Park JS, Berry E, Moghadam A, Stanton P, Hutchinson JN, Andrews B, Faux C, Parnevelas J, Eisenberg LM, Park K, Bolshakov VY, Chung S. Ni P, et al. Among authors: park jj, park js, park jm, park k. Mol Ther Methods Clin Dev. 2019 Apr 8;13:414-430. doi: 10.1016/j.omtm.2019.04.002. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2019. PMID: 31061832 Free PMC article.
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Park GH, et al. Among authors: park js, park jm. Nat Neurosci. 2020 Nov;23(11):1352-1364. doi: 10.1038/s41593-020-00724-1. Epub 2020 Oct 23. Nat Neurosci. 2020. PMID: 33097921 Free PMC article.
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development.
Liu D, Zinski A, Mishra A, Noh H, Park GH, Qin Y, Olorife O, Park JM, Abani CP, Park JS, Fung J, Sawaqed F, Coyle JT, Stahl E, Bendl J, Fullard JF, Roussos P, Zhang X, Stanton PK, Yin C, Huang W, Kim HY, Won H, Cho JH, Chung S. Liu D, et al. Among authors: park gh, park js, park jm. Mol Psychiatry. 2022 Oct;27(10):4218-4233. doi: 10.1038/s41380-022-01654-z. Epub 2022 Jun 14. Mol Psychiatry. 2022. PMID: 35701597
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Shao Z, et al. Among authors: park jj, park jm. Nat Neurosci. 2019 Feb;22(2):229-242. doi: 10.1038/s41593-018-0313-z. Epub 2019 Jan 21. Nat Neurosci. 2019. PMID: 30664768 Free PMC article.
iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function.
Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. Ni P, et al. Among authors: park gh, park js, park jm. Mol Psychiatry. 2020 Nov;25(11):2873-2888. doi: 10.1038/s41380-019-0423-3. Epub 2019 Apr 24. Mol Psychiatry. 2020. PMID: 31019265 Free PMC article.
Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function.
Ni P, Noh H, Park GH, Shao Z, Guan Y, Park JM, Yu S, Park JS, Coyle JT, Weinberger DR, Straub RE, Cohen BM, McPhie DL, Yin C, Huang W, Kim HY, Chung S. Ni P, et al. Among authors: park gh, park js, park jm. Mol Psychiatry. 2020 Nov;25(11):3103-3104. doi: 10.1038/s41380-019-0467-4. Mol Psychiatry. 2020. PMID: 31366918
3,041 results