Park H - Search Results

1

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. Feng Y, et al. Among authors: park h. ACS Chem Biol. 2013 Aug 16;8(8):1747-54. doi: 10.1021/cb3006165. Epub 2013 Jun 10. ACS Chem Biol. 2013. PMID: 23751758 Free PMC article.

2

Discovery of potent and selective covalent inhibitors of JNK.

Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Zhang T, et al. Among authors: park h. Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010. Chem Biol. 2012. PMID: 22284361 Free PMC article.

3

Amino acid derived quinazolines as Rock/PKA inhibitors.

Chowdhury S, Chen YT, Fang X, Grant W, Pocas J, Cameron MD, Ruiz C, Lin L, Park H, Schröter T, Bannister TD, Lograsso PV, Feng Y. Chowdhury S, et al. Among authors: park h. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1592-9. doi: 10.1016/j.bmcl.2013.01.109. Epub 2013 Jan 31. Bioorg Med Chem Lett. 2013. PMID: 23416002

4

Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

Jeso V, Iqbal S, Hernandez P, Cameron MD, Park H, LoGrasso PV, Micalizio GC. Jeso V, et al. Among authors: park h. Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4800-4. doi: 10.1002/anie.201301323. Epub 2013 Apr 2. Angew Chem Int Ed Engl. 2013. PMID: 23554224 No abstract available.

5

Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.

Yin Y, Lin L, Ruiz C, Khan S, Cameron MD, Grant W, Pocas J, Eid N, Park H, Schröter T, Lograsso PV, Feng Y. Yin Y, et al. Among authors: park h. J Med Chem. 2013 May 9;56(9):3568-81. doi: 10.1021/jm400062r. Epub 2013 Apr 25. J Med Chem. 2013. PMID: 23570561

6

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity.

Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Childs-Disney JL, et al. Among authors: park h. ACS Chem Biol. 2014 Feb 21;9(2):538-550. doi: 10.1021/cb4007387. Epub 2013 Dec 16. ACS Chem Biol. 2014. PMID: 24341895 Free PMC article.

7

Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.

Zheng K, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Zheng K, et al. Among authors: park h. J Med Chem. 2014 Dec 11;57(23):10013-30. doi: 10.1021/jm501256y. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25393557 Free PMC article.

8

Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

Yin Y, Zheng K, Eid N, Howard S, Jeong JH, Yi F, Guo J, Park CM, Bibian M, Wu W, Hernandez P, Park H, Wu Y, Luo JL, LoGrasso PV, Feng Y. Yin Y, et al. Among authors: park cm, park h. J Med Chem. 2015 Feb 26;58(4):1846-61. doi: 10.1021/jm501680m. Epub 2015 Feb 4. J Med Chem. 2015. PMID: 25621531 Free PMC article.

9

Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.

Park H, Iqbal S, Hernandez P, Mora R, Zheng K, Feng Y, LoGrasso P. Park H, et al. Sci Rep. 2015 Jan 27;5:8047. doi: 10.1038/srep08047. Sci Rep. 2015. PMID: 25623238 Free PMC article.

10

Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.

Zheng K, Park CM, Iqbal S, Hernandez P, Park H, LoGrasso PV, Feng Y. Zheng K, et al. Among authors: park cm, park h. ACS Med Chem Lett. 2015 Mar 2;6(4):413-8. doi: 10.1021/ml500474d. eCollection 2015 Apr 9. ACS Med Chem Lett. 2015. PMID: 25893042 Free PMC article.

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