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Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
Wu L, Seung E, Xu L, Rao E, Lord DM, Wei RR, Cortez-Retamozo V, Ospina B, Posternak V, Ulinski G, Piepenhagen P, Francesconi E, El-Murr N, Beil C, Kirby P, Li A, Fretland J, Vicente R, Deng G, Dabdoubi T, Cameron B, Bertrand T, Ferrari P, Pouzieux S, Lemoine C, Prades C, Park A, Qiu H, Song Z, Zhang B, Sun F, Chiron M, Rao S, Radošević K, Yang ZY, Nabel GJ. Wu L, et al. Among authors: park a. Nat Cancer. 2020 Jan;1(1):86-98. doi: 10.1038/s43018-019-0004-z. Epub 2019 Nov 18. Nat Cancer. 2020. PMID: 35121834
Engineered Fc-glycosylation switch to eliminate antibody effector function.
Zhou Q, Jaworski J, Zhou Y, Valente D, Cotton J, Honey D, Boudanova E, Beninga J, Rao E, Wei R, Mauriac C, Pan C, Park A, Qiu H. Zhou Q, et al. Among authors: park a. MAbs. 2020 Jan-Dec;12(1):1814583. doi: 10.1080/19420862.2020.1814583. MAbs. 2020. PMID: 32892677 Free PMC article.
Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues.
Zhou Q, Kyazike J, Boudanova E, Drzyzga M, Honey D, Cost R, Hou L, Duffieux F, Brun MP, Park A, Qiu H. Zhou Q, et al. Among authors: park a. Pharmaceuticals (Basel). 2021 Jul 14;14(7):672. doi: 10.3390/ph14070672. Pharmaceuticals (Basel). 2021. PMID: 34358098 Free PMC article.
2,766 results