Parés X - Search Results

1

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors.

Ibrahim AIM, Ikhmais B, Batlle E, AbuHarb WK, Jha V, Jaradat KT, Jiménez R, Pequerul R, Parés X, Farrés J, Pors K. Ibrahim AIM, et al. Among authors: pares x. Molecules. 2021 Sep 23;26(19):5770. doi: 10.3390/molecules26195770. Molecules. 2021. PMID: 34641313 Free PMC article.

2

Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.

Ibrahim AIM, Batlle E, Sneha S, Jiménez R, Pequerul R, Parés X, Rüngeler T, Jha V, Tuccinardi T, Sadiq M, Frame F, Maitland NJ, Farrés J, Pors K. Ibrahim AIM, et al. Among authors: pares x. J Med Chem. 2022 Mar 10;65(5):3833-3848. doi: 10.1021/acs.jmedchem.1c01367. Epub 2022 Feb 25. J Med Chem. 2022. PMID: 35212533 Free PMC article.

3

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

Crespo I, Giménez-Dejoz J, Porté S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Parés X, Ruiz FX, Metwally K, Farrés J. Crespo I, et al. Among authors: pares x. Eur J Med Chem. 2018 May 25;152:160-174. doi: 10.1016/j.ejmech.2018.04.015. Epub 2018 Apr 12. Eur J Med Chem. 2018. PMID: 29705708

4

Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells.

Jiménez R, Pequerul R, Amor A, Lorenzo J, Metwally K, Avilés FX, Parés X, Farrés J. Jiménez R, et al. Among authors: pares x. Chem Biol Interact. 2019 Jun 1;306:123-130. doi: 10.1016/j.cbi.2019.04.004. Epub 2019 Apr 5. Chem Biol Interact. 2019. PMID: 30958995

5

Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases.

Rivas A, Pequerul R, Barracco V, Domínguez M, López S, Jiménez R, Parés X, Alvarez R, Farrés J, de Lera AR. Rivas A, et al. Among authors: pares x. Org Biomol Chem. 2020 Jul 1;18(25):4788-4801. doi: 10.1039/d0ob01084g. Org Biomol Chem. 2020. PMID: 32530010

6

Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3.

Castellví A, Pequerul R, Barracco V, Juanhuix J, Parés X, Farrés J. Castellví A, et al. Among authors: pares x. Commun Biol. 2022 Apr 13;5(1):354. doi: 10.1038/s42003-022-03311-1. Commun Biol. 2022. PMID: 35418200 Free PMC article.

7

Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.

Pequerul R, Vera J, Giménez-Dejoz J, Crespo I, Coines J, Porté S, Rovira C, Parés X, Farrés J. Pequerul R, et al. Among authors: pares x. Arch Biochem Biophys. 2020 Mar 15;681:108256. doi: 10.1016/j.abb.2020.108256. Epub 2020 Jan 7. Arch Biochem Biophys. 2020. PMID: 31923393

8

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition.

Ruiz FX, Parés X, Farrés J. Ruiz FX, et al. Among authors: pares x. Metabolites. 2021 Dec 13;11(12):865. doi: 10.3390/metabo11120865. Metabolites. 2021. PMID: 34940623 Free PMC article. Review.

9

Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.

Ruiz FX, Porté S, Parés X, Farrés J. Ruiz FX, et al. Among authors: pares x. Front Pharmacol. 2012 Apr 17;3:58. doi: 10.3389/fphar.2012.00058. eCollection 2012. Front Pharmacol. 2012. PMID: 22529810 Free PMC article.

10

Aldo-keto reductases in retinoid metabolism: search for substrate specificity and inhibitor selectivity.

Porté S, Xavier Ruiz F, Giménez J, Molist I, Alvarez S, Domínguez M, Alvarez R, de Lera AR, Parés X, Farrés J. Porté S, et al. Among authors: pares x. Chem Biol Interact. 2013 Feb 25;202(1-3):186-94. doi: 10.1016/j.cbi.2012.11.014. Epub 2012 Dec 3. Chem Biol Interact. 2013. PMID: 23220004

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