Papatheodorou P - Search Results

1

Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors.

López-Ureña D, Orozco-Aguilar J, Chaves-Madrigal Y, Ramírez-Mata A, Villalobos-Jimenez A, Ost S, Quesada-Gómez C, Rodríguez C, Papatheodorou P, Chaves-Olarte E. López-Ureña D, et al. Among authors: papatheodorou p. Toxins (Basel). 2019 Jun 17;11(6):348. doi: 10.3390/toxins11060348. Toxins (Basel). 2019. PMID: 31212980 Free PMC article.

2

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

Genisyuerek S, Papatheodorou P, Guttenberg G, Schubert R, Benz R, Aktories K. Genisyuerek S, et al. Among authors: papatheodorou p. Mol Microbiol. 2011 Mar;79(6):1643-54. doi: 10.1111/j.1365-2958.2011.07549.x. Epub 2011 Jan 28. Mol Microbiol. 2011. PMID: 21231971 Free article.

3

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT).

Papatheodorou P, Carette JE, Bell GW, Schwan C, Guttenberg G, Brummelkamp TR, Aktories K. Papatheodorou P, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16422-7. doi: 10.1073/pnas.1109772108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930894 Free PMC article.

4

Identification of the cellular receptor of Clostridium spiroforme toxin.

Papatheodorou P, Wilczek C, Nölke T, Guttenberg G, Hornuss D, Schwan C, Aktories K. Papatheodorou P, et al. Infect Immun. 2012 Apr;80(4):1418-23. doi: 10.1128/IAI.06378-11. Epub 2012 Jan 17. Infect Immun. 2012. PMID: 22252869 Free PMC article.

5

Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts.

Papatheodorou P, Hornuss D, Nölke T, Hemmasi S, Castonguay J, Picchianti M, Aktories K. Papatheodorou P, et al. mBio. 2013 Apr 30;4(3):e00244-13. doi: 10.1128/mBio.00244-13. mBio. 2013. PMID: 23631918 Free PMC article.

6

Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).

Hemmasi S, Czulkies BA, Schorch B, Veit A, Aktories K, Papatheodorou P. Hemmasi S, et al. Among authors: papatheodorou p. J Biol Chem. 2015 May 29;290(22):14031-44. doi: 10.1074/jbc.M115.650523. Epub 2015 Apr 16. J Biol Chem. 2015. PMID: 25882847 Free PMC article.

7

Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins.

Papatheodorou P, Barth H, Minton N, Aktories K. Papatheodorou P, et al. Adv Exp Med Biol. 2018;1050:77-96. doi: 10.1007/978-3-319-72799-8_6. Adv Exp Med Biol. 2018. PMID: 29383665 Review.

8

Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K. Papatheodorou P, et al. FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28. FASEB J. 2019. PMID: 30592645

Taken together, these findings allowed us to identify the SREBP-2 pathway as a suitable target for the development of antitoxin therapeutics against C. difficile toxins A and B.-Papatheodorou, P., Song, S., Lopez-Urena, D., Witte, A., Marques, F., Ost, G. ...

Taken together, these findings allowed us to identify the SREBP-2 pathway as a suitable target for the development of antitoxin therapeutics …

9

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB.

Papatheodorou P, Kindig S, Badilla-Lobo A, Fischer S, Durgun E, Thuraisingam T, Witte A, Song S, Aktories K, Chaves-Olarte E, Rodríguez C, Barth H. Papatheodorou P, et al. Front Microbiol. 2021 Nov 29;12:784856. doi: 10.3389/fmicb.2021.784856. eCollection 2021. Front Microbiol. 2021. PMID: 34912322 Free PMC article.

10

Domperidone Protects Cells from Intoxication with Clostridioides difficile Toxins by Inhibiting Hsp70-Assisted Membrane Translocation.

Braune-Yan M, Jia J, Wahba M, Schmid J, Papatheodorou P, Barth H, Ernst K. Braune-Yan M, et al. Among authors: papatheodorou p. Toxins (Basel). 2023 Jun 7;15(6):384. doi: 10.3390/toxins15060384. Toxins (Basel). 2023. PMID: 37368685 Free PMC article.

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