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A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.
Sblano S, Cerchia C, Laghezza A, Piemontese L, Brunetti L, Leuci R, Gilardi F, Thomas A, Genovese M, Santi A, Tortorella P, Paoli P, Lavecchia A, Loiodice F. Sblano S, et al. Among authors: paoli p. Eur J Med Chem. 2022 May 5;235:114240. doi: 10.1016/j.ejmech.2022.114240. Epub 2022 Mar 16. Eur J Med Chem. 2022. PMID: 35325635
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
Ottanà R, Maccari R, Amuso S, Wolber G, Schuster D, Herdlinger S, Manao G, Camici G, Paoli P. Ottanà R, et al. Among authors: paoli p. Eur J Med Chem. 2012 Apr;50:332-43. doi: 10.1016/j.ejmech.2012.02.012. Epub 2012 Feb 21. Eur J Med Chem. 2012. PMID: 22381357
The effects of CA IX catalysis products within tumor microenvironment.
Santi A, Caselli A, Paoli P, Corti D, Camici G, Pieraccini G, Taddei ML, Serni S, Chiarugi P, Cirri P. Santi A, et al. Among authors: paoli p. Cell Commun Signal. 2013 Oct 29;11:81. doi: 10.1186/1478-811X-11-81. Cell Commun Signal. 2013. PMID: 24168032 Free PMC article.
Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
Ottanà R, Maccari R, Mortier J, Caselli A, Amuso S, Camici G, Rotondo A, Wolber G, Paoli P. Ottanà R, et al. Among authors: paoli p. Eur J Med Chem. 2014 Jan;71:112-27. doi: 10.1016/j.ejmech.2013.11.001. Epub 2013 Nov 11. Eur J Med Chem. 2014. PMID: 24287560
Effect of natural compounds on insulin signaling.
Paoli P, Caselli A, Camici G, Cirri P. Paoli P, et al. Curr Med Chem. 2015;22(1):80-111. doi: 10.2174/0929867321666140815123249. Curr Med Chem. 2015. PMID: 25139055 Review.
Morin: A Promising Natural Drug.
Caselli A, Cirri P, Santi A, Paoli P. Caselli A, et al. Among authors: paoli p. Curr Med Chem. 2016;23(8):774-91. doi: 10.2174/0929867323666160106150821. Curr Med Chem. 2016. PMID: 26018232 Review.
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents.
Ottanà R, Paoli P, Naß A, Lori G, Cardile V, Adornato I, Rotondo A, Graziano ACE, Wolber G, Maccari R. Ottanà R, et al. Among authors: paoli p. Eur J Med Chem. 2017 Feb 15;127:840-858. doi: 10.1016/j.ejmech.2016.10.063. Epub 2016 Nov 1. Eur J Med Chem. 2017. PMID: 27842892
453 results