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Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
Lefranc J, Schulze VK, Hillig RC, Briem H, Prinz F, Mengel A, Heinrich T, Balint J, Rengachari S, Irlbacher H, Stöckigt D, Bömer U, Bader B, Gradl SN, Nising CF, von Nussbaum F, Mumberg D, Panne D, Wengner AM. Lefranc J, et al. Among authors: panne d. J Med Chem. 2020 Jan 23;63(2):601-612. doi: 10.1021/acs.jmedchem.9b01460. Epub 2020 Jan 10. J Med Chem. 2020. PMID: 31859507
Transcription factor dimerization activates the p300 acetyltransferase.
Ortega E, Rengachari S, Ibrahim Z, Hoghoughi N, Gaucher J, Holehouse AS, Khochbin S, Panne D. Ortega E, et al. Among authors: panne d. Nature. 2018 Oct;562(7728):538-544. doi: 10.1038/s41586-018-0621-1. Epub 2018 Oct 15. Nature. 2018. PMID: 30323286 Free PMC article.
Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.
Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S. Goudarzi A, et al. Among authors: panne d. Mol Cell. 2016 Apr 21;62(2):169-180. doi: 10.1016/j.molcel.2016.03.014. Mol Cell. 2016. PMID: 27105113 Free PMC article.
Structure of p300 in complex with acyl-CoA variants.
Kaczmarska Z, Ortega E, Goudarzi A, Huang H, Kim S, Márquez JA, Zhao Y, Khochbin S, Panne D. Kaczmarska Z, et al. Among authors: panne d. Nat Chem Biol. 2017 Jan;13(1):21-29. doi: 10.1038/nchembio.2217. Epub 2016 Oct 31. Nat Chem Biol. 2017. PMID: 27820805 Free PMC article.
Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells.
Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar F, Gérard M, Zhu M, Bargier L, Puthier D, Chuffart F, Bourova-Flin E, Picaud S, Filippakopoulos P, Goudarzi A, Ibrahim Z, Panne D, Rousseaux S, Zhao Y, Khochbin S. Shiota H, et al. Among authors: panne d. Cell Rep. 2018 Sep 25;24(13):3477-3487.e6. doi: 10.1016/j.celrep.2018.08.069. Cell Rep. 2018. PMID: 30257209 Free article.
33 results