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Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.
Feuerstein GZ, Zaleska MM, Krams M, Wang X, Day M, Rutkowski JL, Finklestein SP, Pangalos MN, Poole M, Stiles GL, Ruffolo RR, Walsh FL. Feuerstein GZ, et al. Among authors: pangalos mn. J Cereb Blood Flow Metab. 2008 Jan;28(1):217-9. doi: 10.1038/sj.jcbfm.9600516. Epub 2007 Jun 20. J Cereb Blood Flow Metab. 2008. PMID: 17579658 Review.
Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke.
Chavez JC, Zaleska MM, Wang X, Wood A, Hurko O, Pangalos MN, Feuerstein GZ. Chavez JC, et al. Among authors: pangalos mn. J Cereb Blood Flow Metab. 2009 Jan;29(1):217-9. doi: 10.1038/jcbfm.2008.103. Epub 2008 Sep 3. J Cereb Blood Flow Metab. 2009. PMID: 18766199
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.
Riddell DR, Zhou H, Atchison K, Warwick HK, Atkinson PJ, Jefferson J, Xu L, Aschmies S, Kirksey Y, Hu Y, Wagner E, Parratt A, Xu J, Li Z, Zaleska MM, Jacobsen JS, Pangalos MN, Reinhart PH. Riddell DR, et al. Among authors: pangalos mn. J Neurosci. 2008 Nov 5;28(45):11445-53. doi: 10.1523/JNEUROSCI.1972-08.2008. J Neurosci. 2008. PMID: 18987181 Free PMC article.
Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia.
Liang S, Pong K, Gonzales C, Chen Y, Ling HP, Mark RJ, Boschelli F, Boschelli DH, Ye F, Barrios Sosa AC, Mansour TS, Frost P, Wood A, Pangalos MN, Zaleska MM. Liang S, et al. Among authors: pangalos mn. J Pharmacol Exp Ther. 2009 Dec;331(3):827-35. doi: 10.1124/jpet.109.156562. Epub 2009 Sep 9. J Pharmacol Exp Ther. 2009. PMID: 19741150
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS. Martone RL, et al. Among authors: pangalos mn. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11. J Pharmacol Exp Ther. 2009. PMID: 19671883
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities.
Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F, von Schack D, McDonald L, Zaleska MM, Wood A, Reinhart PH, Magolda RL, Skotnicki J, Pangalos MN, Koehn FE, Carter GT, Abou-Gharbia M, Graziani EI. Ruan B, et al. Among authors: pangalos mn. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. doi: 10.1073/pnas.0710424105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162540 Free PMC article.
154 results