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Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model.
Assis PA, De Figueiredo-Pontes LL, Lima AS, Leão V, Cândido LA, Pintão CT, Garcia AB, Saggioro FP, Panepucci RA, Chahud F, Nagler A, Falcão RP, Rego EM. Assis PA, et al. Among authors: panepucci ra. J Exp Clin Cancer Res. 2015 Jun 23;34(1):65. doi: 10.1186/s13046-015-0181-2. J Exp Clin Cancer Res. 2015. PMID: 26099922 Free PMC article.
Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway.
de Figueiredo-Pontes LL, Assis PA, Santana-Lemos BA, Jácomo RH, Lima AS, Garcia AB, Thomé CH, Araújo AG, Panepucci RA, Zago MA, Nagler A, Falcão RP, Rego EM. de Figueiredo-Pontes LL, et al. Among authors: panepucci ra. PLoS One. 2011;6(10):e26713. doi: 10.1371/journal.pone.0026713. Epub 2011 Oct 28. PLoS One. 2011. PMID: 22053203 Free PMC article.
PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma.
Proto-Siqueira R, Figueiredo-Pontes LL, Panepucci RA, Garcia AB, Rizzatti EG, Nascimento FM, Ishikawa HC, Larson RE, Falcão RP, Simpson AJ, Gout I, Filonenko V, Rego EM, Zago MA. Proto-Siqueira R, et al. Among authors: panepucci ra. Leuk Res. 2006 Nov;30(11):1333-9. doi: 10.1016/j.leukres.2006.02.031. Epub 2006 Apr 18. Leuk Res. 2006. PMID: 16620968
The expression of DeltaNTP73, TATP73 and TP53 genes in acute myeloid leukaemia is associated with recurrent cytogenetic abnormalities and in vitro susceptibility to cytarabine cytotoxicity.
Lucena-Araujo AR, Panepucci RA, dos Santos GA, Jácomo RH, Santana-Lemos BA, Lima AS, Garcia AB, Araújo AG, Falcão RP, Rego EM. Lucena-Araujo AR, et al. Among authors: panepucci ra. Br J Haematol. 2008 Jul;142(1):74-8. doi: 10.1111/j.1365-2141.2008.07160.x. Epub 2008 Apr 17. Br J Haematol. 2008. PMID: 18422993 Free article.
The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.
de Paula Careta F, Gobessi S, Panepucci RA, Bojnik E, Morato de Oliveira F, Mazza Matos D, Falcão RP, Laurenti L, Zago MA, Efremov DG. de Paula Careta F, et al. Among authors: panepucci ra. Haematologica. 2012 Aug;97(8):1246-54. doi: 10.3324/haematol.2011.054668. Epub 2012 Feb 13. Haematologica. 2012. PMID: 22331265 Free PMC article.
DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine.
Sangiorgi B, De Freitas HT, Schiavinato JL, Leão V, Haddad R, Orellana MD, Faça VM, Ferreira GA, Covas DT, Zago MA, Panepucci RA. Sangiorgi B, et al. Among authors: panepucci ra. Cytotherapy. 2016 Jul;18(7):846-59. doi: 10.1016/j.jcyt.2016.04.004. Cytotherapy. 2016. PMID: 27260206
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