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Targeting Nrf2 in Protection Against Renal Disease.
Guerrero-Hue M, Farre-Alins V, Palomino-Antolin A, Parada E, Rubio-Navarro A, Egido J, Egea J, Moreno JA. Guerrero-Hue M, et al. Curr Med Chem. 2017;24(33):3583-3605. doi: 10.2174/0929867324666170511120814. Curr Med Chem. 2017. PMID: 28494744 Review.
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
Bautista-Aguilera ÓM, Hagenow S, Palomino-Antolin A, Farré-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janočková J, Kalinowsky L, Proschak E, Iriepa I, Moraleda I, Schwed JS, Romero Martínez A, López-Muñoz F, Chioua M, Egea J, Ramsay RR, Marco-Contelles J, Stark H. Bautista-Aguilera ÓM, et al. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12765-12769. doi: 10.1002/anie.201706072. Epub 2017 Sep 1. Angew Chem Int Ed Engl. 2017. PMID: 28861918
Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models.
Parada E, Casas AI, Palomino-Antolin A, Gómez-Rangel V, Rubio-Navarro A, Farré-Alins V, Narros-Fernandez P, Guerrero-Hue M, Moreno JA, Rosa JM, Roda JM, Hernández-García BJ, Egea J. Parada E, et al. Br J Pharmacol. 2019 Aug;176(15):2764-2779. doi: 10.1111/bph.14703. Epub 2019 Jun 17. Br J Pharmacol. 2019. PMID: 31074003 Free PMC article.
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
Malek R, Arribas RL, Palomino-Antolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I, Diez-Iriepa D, Godyń J, Panek D, Malawska B, Głuch-Lutwin M, Mordyl B, Siwek A, Chabchoub F, Marco-Contelles J, Kiec-Kononowicz K, Egea J, de Los Ríos C, Ismaili L. Malek R, et al. J Med Chem. 2019 Dec 26;62(24):11416-11422. doi: 10.1021/acs.jmedchem.9b00937. Epub 2019 Dec 5. J Med Chem. 2019. PMID: 31724859
Na+ controls hypoxic signalling by the mitochondrial respiratory chain.
Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo Á, López-Montero I, Martínez-Del-Pozo Á, Egea J, López MG, Elrod JW, Ruíz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A. Hernansanz-Agustín P, et al. Nature. 2020 Oct;586(7828):287-291. doi: 10.1038/s41586-020-2551-y. Epub 2020 Jul 29. Nature. 2020. PMID: 32728214 Free PMC article.
Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux.
Farré-Alins V, Narros-Fernández P, Palomino-Antolín A, Decouty-Pérez C, Lopez-Rodriguez AB, Parada E, Muñoz-Montero A, Gómez-Rangel V, López-Muñoz F, Ramos E, González-Rodríguez Á, Gandía L, Romero A, Egea J. Farré-Alins V, et al. Among authors: palomino antolin a. Antioxidants (Basel). 2020 Dec 18;9(12):1299. doi: 10.3390/antiox9121299. Antioxidants (Basel). 2020. PMID: 33353046 Free PMC article.
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