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Metformin acts in the gut and induces gut-liver crosstalk.
Tobar N, Rocha GZ, Santos A, Guadagnini D, Assalin HB, Camargo JA, Gonçalves AESS, Pallis FR, Oliveira AG, Rocco SA, Neto RM, de Sousa IL, Alborghetti MR, Sforça ML, Rodrigues PB, Ludwig RG, Vanzela EC, Brunetto SQ, Boer PA, Gontijo JAR, Geloneze B, Carvalho CRO, Prada PO, Folli F, Curi R, Mori MA, Vinolo MAR, Ramos CD, Franchini KG, Tormena CF, Saad MJA. Tobar N, et al. Among authors: pallis fr. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2211933120. doi: 10.1073/pnas.2211933120. Epub 2023 Jan 19. Proc Natl Acad Sci U S A. 2023. PMID: 36656866 Free PMC article.
Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15.
Fertrin KY, Lanaro C, Franco-Penteado CF, de Albuquerque DM, de Mello MR, Pallis FR, Bezerra MA, Hatzlhofer BL, Olbina G, Saad ST, da Silva Araújo A, Westerman M, Costa FF. Fertrin KY, et al. Among authors: pallis fr. Am J Hematol. 2014 Apr;89(4):385-90. doi: 10.1002/ajh.23649. Am J Hematol. 2014. PMID: 24860871 Free article.