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Detecting different amorphous - Amorphous phase separation patterns in co-amorphous mixtures with high resolution imaging FTIR spectroscopy.
Eur J Pharm Biopharm. 2022 Nov;180:161-169. doi: 10.1016/j.ejpb.2022.09.011. Epub 2022 Sep 17.
Eur J Pharm Biopharm. 2022.
PMID: 36122786
Free article.
Detection of amorphous-amorphous phase separation in small molecular co-amorphous mixtures with SEM-EDS.
Pajula K, Hyyryläinen J, Koistinen A, Leskinen JTT, Korhonen O.
Pajula K, et al.
Eur J Pharm Biopharm. 2020 May;150:43-49. doi: 10.1016/j.ejpb.2020.03.002. Epub 2020 Mar 6.
Eur J Pharm Biopharm. 2020.
PMID: 32151730
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Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems.
Kilpeläinen T, Pajula K, Ervasti T, Uurasjärvi E, Koistinen A, Korhonen O.
Kilpeläinen T, et al. Among authors: pajula k.
Eur J Pharm Biopharm. 2020 Oct;155:49-54. doi: 10.1016/j.ejpb.2020.08.007. Epub 2020 Aug 11.
Eur J Pharm Biopharm. 2020.
PMID: 32795500
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Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram.
Pajula K, Taskinen M, Lehto VP, Ketolainen J, Korhonen O.
Pajula K, et al.
Mol Pharm. 2010 Jun 7;7(3):795-804. doi: 10.1021/mp900304p.
Mol Pharm. 2010.
PMID: 20361760
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Computational approach for fast screening of small molecular candidates to inhibit crystallization in amorphous drugs.
Pajula K, Lehto VP, Ketolainen J, Korhonen O.
Pajula K, et al.
Mol Pharm. 2012 Oct 1;9(10):2844-55. doi: 10.1021/mp300135h. Epub 2012 Aug 27.
Mol Pharm. 2012.
PMID: 22867030
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Phase separation in coamorphous systems: in silico prediction and the experimental challenge of detection.
Pajula K, Wittoek L, Lehto VP, Ketolainen J, Korhonen O.
Pajula K, et al.
Mol Pharm. 2014 Jul 7;11(7):2271-9. doi: 10.1021/mp400712m. Epub 2014 May 23.
Mol Pharm. 2014.
PMID: 24824610
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Rational excipient selection for co-amorphous formulations.
Korhonen O, Pajula K, Laitinen R.
Korhonen O, et al. Among authors: pajula k.
Expert Opin Drug Deliv. 2017 Apr;14(4):551-569. doi: 10.1080/17425247.2016.1198770. Epub 2016 Jun 20.
Expert Opin Drug Deliv. 2017.
PMID: 27267873
Review.
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Production and stability of amorphous solid dispersions produced by a Freeze-drying method from DMSO.
Valkama E, Haluska O, Lehto VP, Korhonen O, Pajula K.
Valkama E, et al. Among authors: pajula k.
Int J Pharm. 2021 Sep 5;606:120902. doi: 10.1016/j.ijpharm.2021.120902. Epub 2021 Jul 19.
Int J Pharm. 2021.
PMID: 34293468
Free article.
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