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Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.
Jutzi JS, Basu T, Pellmann M, Kaiser S, Steinemann D, Sanders MA, Hinai ASA, Zeilemaker A, Bojtine Kovacs S, Koellerer C, Ostendorp J, Aumann K, Wang W, Raffoux E, Cassinat B, Bullinger L, Schlegelberger B, Valk PJM, Pahl HL. Jutzi JS, et al. Among authors: pahl hl. Blood. 2019 Apr 18;133(16):1766-1777. doi: 10.1182/blood-2018-09-875047. Epub 2019 Feb 12. Blood. 2019. PMID: 30755419 Free PMC article.
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.
Fleischman AG, Aichberger KJ, Luty SB, Bumm TG, Petersen CL, Doratotaj S, Vasudevan KB, LaTocha DH, Yang F, Press RD, Loriaux MM, Pahl HL, Silver RT, Agarwal A, O'Hare T, Druker BJ, Bagby GC, Deininger MW. Fleischman AG, et al. Among authors: pahl hl. Blood. 2011 Dec 8;118(24):6392-8. doi: 10.1182/blood-2011-04-348144. Epub 2011 Aug 22. Blood. 2011. PMID: 21860020 Free PMC article.
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
Kaufmann KB, Gründer A, Hadlich T, Wehrle J, Gothwal M, Bogeska R, Seeger TS, Kayser S, Pham KB, Jutzi JS, Ganzenmüller L, Steinemann D, Schlegelberger B, Wagner JM, Jung M, Will B, Steidl U, Aumann K, Werner M, Günther T, Schüle R, Rambaldi A, Pahl HL. Kaufmann KB, et al. Among authors: pahl hl. J Exp Med. 2012 Jan 16;209(1):35-50. doi: 10.1084/jem.20110540. Epub 2012 Jan 9. J Exp Med. 2012. PMID: 22231305 Free PMC article.
A JAK-in-the-cell cycle.
Pahl HL. Pahl HL. Blood. 2012 Feb 2;119(5):1096-7. doi: 10.1182/blood-2011-11-393462. Blood. 2012. PMID: 22308276 Free article.
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.
Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F, Schwemmers S, Gründer A, Peeken JC, Gothwal M, Wehrle J, Aumann K, Hamdi K, Dierks C, Kamar Wang W, Döhner K, Jansen JH, Pahl HL. Jutzi JS, et al. Among authors: pahl hl. J Exp Med. 2013 May 6;210(5):1003-19. doi: 10.1084/jem.20120521. J Exp Med. 2013. PMID: 23589569 Free PMC article.
156 results