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Page 1
Structural basis for ion selectivity in potassium-selective channelrhodopsins.
Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE. Tajima S, et al. Among authors: paggi jm. Cell. 2023 Sep 28;186(20):4325-4344.e26. doi: 10.1016/j.cell.2023.08.009. Epub 2023 Aug 30. Cell. 2023. PMID: 37652010 Free PMC article.
Structure of the µ-opioid receptor-Gi protein complex.
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK. Koehl A, et al. Among authors: paggi jm. Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13. Nature. 2018. PMID: 29899455 Free PMC article.
Crystal structure of the natural anion-conducting channelrhodopsin GtACR1.
Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK, Deisseroth K. Kim YS, et al. Among authors: paggi jm. Nature. 2018 Sep;561(7723):343-348. doi: 10.1038/s41586-018-0511-6. Epub 2018 Aug 29. Nature. 2018. PMID: 30158696 Free PMC article.
Structural mechanisms of selectivity and gating in anion channelrhodopsins.
Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK, Deisseroth K. Kato HE, et al. Among authors: paggi jm. Nature. 2018 Sep;561(7723):349-354. doi: 10.1038/s41586-018-0504-5. Epub 2018 Aug 29. Nature. 2018. PMID: 30158697 Free PMC article.
Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine.
Kishi KE, Kim YS, Fukuda M, Inoue M, Kusakizako T, Wang PY, Ramakrishnan C, Byrne EFX, Thadhani E, Paggi JM, Matsui TE, Yamashita K, Nagata T, Konno M, Quirin S, Lo M, Benster T, Uemura T, Liu K, Shibata M, Nomura N, Iwata S, Nureki O, Dror RO, Inoue K, Deisseroth K, Kato HE. Kishi KE, et al. Among authors: paggi jm. Cell. 2022 Feb 17;185(4):672-689.e23. doi: 10.1016/j.cell.2022.01.007. Epub 2022 Feb 2. Cell. 2022. PMID: 35114111 Free PMC article.
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G. Qu Q, et al. Among authors: paggi jm. Nat Chem Biol. 2023 Apr;19(4):423-430. doi: 10.1038/s41589-022-01208-y. Epub 2022 Nov 21. Nat Chem Biol. 2023. PMID: 36411392
A non-canonical mechanism of GPCR activation.
Powers AS, Khan A, Paggi JM, Latorraca NR, Souza S, Salvo JD, Lu J, Soisson SM, Johnston JM, Weinglass AB, Dror RO. Powers AS, et al. Among authors: paggi jm. bioRxiv [Preprint]. 2023 Aug 15:2023.08.14.553154. doi: 10.1101/2023.08.14.553154. bioRxiv. 2023. PMID: 37645874 Free PMC article. Preprint.
Geometric Deep Learning for Structure-Based Ligand Design.
Powers AS, Yu HH, Suriana P, Koodli RV, Lu T, Paggi JM, Dror RO. Powers AS, et al. Among authors: paggi jm. ACS Cent Sci. 2023 Nov 17;9(12):2257-2267. doi: 10.1021/acscentsci.3c00572. eCollection 2023 Dec 27. ACS Cent Sci. 2023. PMID: 38161364 Free PMC article.
17 results