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A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: paetzel m. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Structure of the catalytic domain of glucoamylase from Aspergillus niger.
Lee J, Paetzel M. Lee J, et al. Among authors: paetzel m. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):188-92. doi: 10.1107/S1744309110049390. Epub 2011 Jan 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21301084 Free PMC article.
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus.
Alexander JAN, Worrall LJ, Hu J, Vuckovic M, Satishkumar N, Poon R, Sobhanifar S, Rosell FI, Jenkins J, Chiang D, Mosimann WA, Chambers HF, Paetzel M, Chatterjee SS, Strynadka NCJ. Alexander JAN, et al. Among authors: paetzel m. Nature. 2023 Jan;613(7943):375-382. doi: 10.1038/s41586-022-05583-3. Epub 2023 Jan 4. Nature. 2023. PMID: 36599987 Free PMC article.
Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism.
Paetzel M, Dalbey RE, Strynadka NC. Paetzel M, et al. J Biol Chem. 2002 Mar 15;277(11):9512-9. doi: 10.1074/jbc.M110983200. Epub 2001 Dec 10. J Biol Chem. 2002. PMID: 11741964 Free article.
The structure was solved by molecular replacement and refined to 2.4 A resolution in a different space group (P4(1)2(1)2) from that of the previously published acyl-enzyme inhibitor-bound structure (P2(1)2(1)2) (Paetzel, M., Dalbey, R.E., and Strynadka, N.C.J. (1998 …
The structure was solved by molecular replacement and refined to 2.4 A resolution in a different space group (P4(1)2(1)2) from that of the p …
Crystal structure of the class D beta-lactamase OXA-10.
Paetzel M, Danel F, de Castro L, Mosimann SC, Page MG, Strynadka NC. Paetzel M, et al. Nat Struct Biol. 2000 Oct;7(10):918-25. doi: 10.1038/79688. Nat Struct Biol. 2000. PMID: 11017203
66 results