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The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors.
Manfroni G, Cannalire R, Barreca ML, Kaushik-Basu N, Leyssen P, Winquist J, Iraci N, Manvar D, Paeshuyse J, Guhamazumder R, Basu A, Sabatini S, Tabarrini O, Danielson UH, Neyts J, Cecchetti V. Manfroni G, et al. Among authors: paeshuyse j. J Med Chem. 2014 Mar 13;57(5):1952-63. doi: 10.1021/jm401362f. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24131104 Free PMC article.
New pyrazolobenzothiazine derivatives as hepatitis C virus NS5B polymerase palm site I inhibitors.
Manfroni G, Manvar D, Barreca ML, Kaushik-Basu N, Leyssen P, Paeshuyse J, Cannalire R, Iraci N, Basu A, Chudaev M, Zamperini C, Dreassi E, Sabatini S, Tabarrini O, Neyts J, Cecchetti V. Manfroni G, et al. Among authors: paeshuyse j. J Med Chem. 2014 Apr 24;57(8):3247-62. doi: 10.1021/jm401688h. Epub 2014 Apr 2. J Med Chem. 2014. PMID: 24654886 Free PMC article.
Substituted 2,6-bis(benzimidazol-2-yl)pyridines: a novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase.
Musiu S, Pürstinger G, Stallinger S, Vrancken R, Haegeman A, Koenen F, Leyssen P, Froeyen M, Neyts J, Paeshuyse J. Musiu S, et al. Among authors: paeshuyse j. Antiviral Res. 2014 Jun;106:71-9. doi: 10.1016/j.antiviral.2014.03.010. Epub 2014 Mar 27. Antiviral Res. 2014. PMID: 24680957
Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
Rivero-Buceta E, Carrero P, Doyagüez EG, Madrona A, Quesada E, Camarasa MJ, Peréz-Pérez MJ, Leyssen P, Paeshuyse J, Balzarini J, Neyts J, San-Félix A. Rivero-Buceta E, et al. Among authors: paeshuyse j. Eur J Med Chem. 2015 Mar 6;92:656-71. doi: 10.1016/j.ejmech.2015.01.033. Epub 2015 Jan 17. Eur J Med Chem. 2015. PMID: 25617695 Free article.
78 results