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Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T. Schepers M, et al. Among authors: paes d. Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28. Brain Behav Immun. 2023. PMID: 36584795 Free article.
Phosphodiesterase Type 4 Inhibition in CNS Diseases.
Blokland A, Heckman P, Vanmierlo T, Schreiber R, Paes D, Prickaerts J. Blokland A, et al. Among authors: paes d. Trends Pharmacol Sci. 2019 Dec;40(12):971-985. doi: 10.1016/j.tips.2019.10.006. Epub 2019 Nov 5. Trends Pharmacol Sci. 2019. PMID: 31704172 Review.
Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer's disease.
Paes D, Lardenoije R, Carollo RM, Roubroeks JAY, Schepers M, Coleman P, Mastroeni D, Delvaux E, Pishva E, Lunnon K, Vanmierlo T, van den Hove D, Prickaerts J. Paes D, et al. Neurobiol Aging. 2021 Jan;97:56-64. doi: 10.1016/j.neurobiolaging.2020.10.004. Epub 2020 Oct 9. Neurobiol Aging. 2021. PMID: 33157432 Free article.
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity.
Rombaut B, Kessels S, Schepers M, Tiane A, Paes D, Solomina Y, Piccart E, van den Hove D, Brône B, Prickaerts J, Vanmierlo T. Rombaut B, et al. Among authors: paes d. Theranostics. 2021 Jan 1;11(5):2080-2097. doi: 10.7150/thno.50701. eCollection 2021. Theranostics. 2021. PMID: 33500712 Free PMC article. Review.
36 results