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A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability.
Voigt EA, Gerhardt A, Hanson D, Jennewein MF, Battisti P, Reed S, Singh J, Mohamath R, Bakken J, Beaver S, Press C, Soon-Shiong P, Paddon CJ, Fox CB, Casper C. Voigt EA, et al. Among authors: paddon cj. NPJ Vaccines. 2022 Nov 2;7(1):136. doi: 10.1038/s41541-022-00549-y. NPJ Vaccines. 2022. PMID: 36323666 Free PMC article.
Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions.
Fisher KJ, Kinsey R, Mohamath R, Phan T, Liang H, Orr MT, Lykins WR, Guderian JA, Bakken J, Argilla D, Ramer-Denisoff G, Larson E, Qi Y, Sivananthan S, Smolyar K, Carter D, Paddon CJ, Fox CB. Fisher KJ, et al. Among authors: paddon cj. NPJ Vaccines. 2023 Feb 16;8(1):14. doi: 10.1038/s41541-023-00608-y. NPJ Vaccines. 2023. PMID: 36797262 Free PMC article.
Kilo-Scale GMP Synthesis of Renewable Semisynthetic Vaccine-Grade Squalene.
Fisher KJ, Shirtcliff L, Buchanan G, Thompson AW, Woolard FX, LaMunyon DH, Marshall JL, Baranouskas MB, Voelker RB, Lusk JS, Wells CE, Mohamath R, Kinsey R, Lykins WR, Ramer-Denisoff G, Fox CB, Paddon CJ, McPhee D. Fisher KJ, et al. Among authors: paddon cj. Org Process Res Dev. 2023 Dec 15;27(12):2317-2328. doi: 10.1021/acs.oprd.3c00300. Epub 2023 Nov 16. Org Process Res Dev. 2023. PMID: 38524776
High-level semi-synthetic production of the potent antimalarial artemisinin.
Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. Paddon CJ, et al. Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10. Nature. 2013. PMID: 23575629
De novo sequencing, assembly and analysis of the genome of the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D, a model for modern industrial biotechnology.
Nijkamp JF, van den Broek M, Datema E, de Kok S, Bosman L, Luttik MA, Daran-Lapujade P, Vongsangnak W, Nielsen J, Heijne WH, Klaassen P, Paddon CJ, Platt D, Kötter P, van Ham RC, Reinders MJ, Pronk JT, de Ridder D, Daran JM. Nijkamp JF, et al. Among authors: paddon cj. Microb Cell Fact. 2012 Mar 26;11:36. doi: 10.1186/1475-2859-11-36. Microb Cell Fact. 2012. PMID: 22448915 Free PMC article.
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