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Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis.
Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. Ozmadenci D, et al. Among authors: pachter ja. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2117065119. doi: 10.1073/pnas.2117065119. Epub 2022 Apr 25. Proc Natl Acad Sci U S A. 2022. PMID: 35467979 Free PMC article.
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship.
Shapiro IM, Kolev VN, Vidal CM, Kadariya Y, Ring JE, Wright Q, Weaver DT, Menges C, Padval M, McClatchey AI, Xu Q, Testa JR, Pachter JA. Shapiro IM, et al. Among authors: pachter ja. Sci Transl Med. 2014 May 21;6(237):237ra68. doi: 10.1126/scitranslmed.3008639. Sci Transl Med. 2014. PMID: 24848258 Free PMC article.
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.
Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS. Feng X, et al. Among authors: pachter ja. Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14. Cancer Cell. 2019. PMID: 30773340 Free PMC article.
FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.
Diaz Osterman CJ, Ozmadenci D, Kleinschmidt EG, Taylor KN, Barrie AM, Jiang S, Bean LM, Sulzmaier FJ, Jean C, Tancioni I, Anderson K, Uryu S, Cordasco EA, Li J, Chen XL, Fu G, Ojalill M, Rappu P, Heino J, Mark AM, Xu G, Fisch KM, Kolev VN, Weaver DT, Pachter JA, Győrffy B, McHale MT, Connolly DC, Molinolo A, Stupack DG, Schlaepfer DD. Diaz Osterman CJ, et al. Among authors: pachter ja. Elife. 2019 Sep 3;8:e47327. doi: 10.7554/eLife.47327. Elife. 2019. PMID: 31478830 Free PMC article.
Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma.
Meads MB, Fang B, Mathews L, Gemmer J, Nong L, Rosado-Lopez I, Nguyen T, Ring JE, Matsui W, MacLeod AR, Pachter JA, Hazlehurst LA, Koomen JM, Shain KH. Meads MB, et al. Among authors: pachter ja. Oncogene. 2016 May;35(21):2723-34. doi: 10.1038/onc.2015.334. Epub 2015 Sep 21. Oncogene. 2016. PMID: 26387544 Free PMC article.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Serrels A, Lund T, Serrels B, Byron A, McPherson RC, von Kriegsheim A, Gómez-Cuadrado L, Canel M, Muir M, Ring JE, Maniati E, Sims AH, Pachter JA, Brunton VG, Gilbert N, Anderton SM, Nibbs RJ, Frame MC. Serrels A, et al. Among authors: pachter ja. Cell. 2015 Sep 24;163(1):160-73. doi: 10.1016/j.cell.2015.09.001. Cell. 2015. PMID: 26406376 Free PMC article.
Focal Adhesion Kinase as a Potential Target in AML and MDS.
Carter BZ, Mak PY, Wang X, Yang H, Garcia-Manero G, Mak DH, Mu H, Ruvolo VR, Qiu Y, Coombes K, Zhang N, Ragon B, Weaver DT, Pachter JA, Kornblau S, Andreeff M. Carter BZ, et al. Among authors: pachter ja. Mol Cancer Ther. 2017 Jun;16(6):1133-1144. doi: 10.1158/1535-7163.MCT-16-0719. Epub 2017 Mar 7. Mol Cancer Ther. 2017. PMID: 28270436 Free PMC article.
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
Begum A, Ewachiw T, Jung C, Huang A, Norberg KJ, Marchionni L, McMillan R, Penchev V, Rajeshkumar NV, Maitra A, Wood L, Wang C, Wolfgang C, DeJesus-Acosta A, Laheru D, Shapiro IM, Padval M, Pachter JA, Weaver DT, Rasheed ZA, Matsui W. Begum A, et al. Among authors: pachter ja. PLoS One. 2017 Jul 10;12(7):e0180181. doi: 10.1371/journal.pone.0180181. eCollection 2017. PLoS One. 2017. PMID: 28692661 Free PMC article.
81 results