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Page 1
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
Cinato M, Mardani I, Miljanovic A, Drevinge C, Laudette M, Bollano E, Henricsson M, Tolö J, Bauza Thorbrügge M, Levin M, Lindbom M, Arif M, Pacher P, Andersson L, Olofsson CS, Borén J, Levin MC. Cinato M, et al. Among authors: pacher p. Life Sci Alliance. 2023 Jan 30;6(4):e202201690. doi: 10.26508/lsa.202201690. Print 2023 Apr. Life Sci Alliance. 2023. PMID: 36717246 Free PMC article.
Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain.
Gulej R, Nyúl-Tóth Á, Ahire C, DelFavero J, Balasubramanian P, Kiss T, Tarantini S, Benyo Z, Pacher P, Csik B, Yabluchanskiy A, Mukli P, Kuan-Celarier A, Krizbai IA, Campisi J, Sonntag WE, Csiszar A, Ungvari Z. Gulej R, et al. Among authors: pacher p. Geroscience. 2023 Oct;45(5):2983-3002. doi: 10.1007/s11357-023-00870-x. Epub 2023 Aug 29. Geroscience. 2023. PMID: 37642933 Free PMC article.
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.
Wagner J, Park LM, Mukhopadhyay P, Matyas C, Trojnar E, Damadzic R, Jung J, Bell AS, Mavromatis LA, Hamandi AM, Rosoff DB, Vendruscolo LF, Koob GF, Pacher P, Lohoff FW. Wagner J, et al. Among authors: pacher p. Brain Behav Immun. 2024 Apr 22;119:494-506. doi: 10.1016/j.bbi.2024.04.022. Online ahead of print. Brain Behav Immun. 2024. PMID: 38657842 Free article.
NASH triggers cardiometabolic HFpEF in aging mice.
Kucsera D, Ruppert M, Sayour NV, Tóth VE, Kovács T, Hegedűs ZI, Onódi Z, Fábián A, Kovács A, Radovits T, Merkely B, Pacher P, Ferdinandy P, Varga ZV. Kucsera D, et al. Among authors: pacher p. Geroscience. 2024 Apr 17. doi: 10.1007/s11357-024-01153-9. Online ahead of print. Geroscience. 2024. PMID: 38630423
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study.
Rosoff DB, Bell AS, Mavromatis LA, Hamandi A, Park L, Jung J, Wagner J, Pacher P, Ray D, Davey Smith G, Lohoff FW. Rosoff DB, et al. Among authors: pacher p. Circ Genom Precis Med. 2024 Feb;17(1):e004224. doi: 10.1161/CIRCGEN.122.004224. Epub 2024 Jan 23. Circ Genom Precis Med. 2024. PMID: 38258565 No abstract available.
PCSK9, A Promising Novel Target for Age-Related Cardiovascular Dysfunction.
Matyas C, Trojnar E, Zhao S, Arif M, Mukhopadhyay P, Kovacs A, Fabian A, Tokodi M, Bagyura Z, Merkely B, Kohidai L, Lajko E, Takacs A, He Y, Gao B, Paloczi J, Lohoff FW, Haskó G, Ding WX, Pacher P. Matyas C, et al. Among authors: pacher p. JACC Basic Transl Sci. 2023 Sep 13;8(10):1334-1353. doi: 10.1016/j.jacbts.2023.06.005. eCollection 2023 Oct. JACC Basic Transl Sci. 2023. PMID: 38094682 Free PMC article.
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence.
Jiang M, Huizenga MCW, Wirt JL, Paloczi J, Amedi A, van den Berg RJBHN, Benz J, Collin L, Deng H, Di X, Driever WF, Florea BI, Grether U, Janssen APA, Hankemeier T, Heitman LH, Lam TW, Mohr F, Pavlovic A, Ruf I, van den Hurk H, Stevens AF, van der Vliet D, van der Wel T, Wittwer MB, van Boeckel CAA, Pacher P, Hohmann AG, van der Stelt M. Jiang M, et al. Among authors: pacher p. Nat Commun. 2023 Dec 5;14(1):8039. doi: 10.1038/s41467-023-43606-3. Nat Commun. 2023. PMID: 38052772 Free PMC article.
Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction.
Sayour NV, Tóth VÉ, Nagy RN, Vörös I, Gergely TG, Onódi Z, Nagy N, Bödör C, Váradi B, Ruppert M, Radovits T, Bleckwedel F, Zelarayán LC, Pacher P, Ágg B, Görbe A, Ferdinandy P, Varga ZV. Sayour NV, et al. Among authors: pacher p. Int J Mol Sci. 2023 Sep 7;24(18):13826. doi: 10.3390/ijms241813826. Int J Mol Sci. 2023. PMID: 37762130 Free PMC article.
385 results