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Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production: Evidence of a multitarget compound.
Borges PV, Moret KH, Raghavendra NM, Maramaldo Costa TE, Monteiro AP, Carneiro AB, Pacheco P, Temerozo JR, Bou-Habib DC, das Graças Henriques M, Penido C. Borges PV, et al. Among authors: pacheco p. Pharmacol Res. 2017 Jan;115:65-77. doi: 10.1016/j.phrs.2016.09.015. Epub 2016 Sep 15. Pharmacol Res. 2017. PMID: 27641928
Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon.
Silva AR, Pacheco P, Vieira-de-Abreu A, Maya-Monteiro CM, D'Alegria B, Magalhães KG, de Assis EF, Bandeira-Melo C, Castro-Faria-Neto HC, Bozza PT. Silva AR, et al. Among authors: pacheco p. Biochim Biophys Acta. 2009 Nov;1791(11):1066-75. doi: 10.1016/j.bbalip.2009.06.004. Epub 2009 Jun 30. Biochim Biophys Acta. 2009. PMID: 19573621
Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response.
Pacheco P, Vieira-de-Abreu A, Gomes RN, Barbosa-Lima G, Wermelinger LB, Maya-Monteiro CM, Silva AR, Bozza MT, Castro-Faria-Neto HC, Bandeira-Melo C, Bozza PT. Pacheco P, et al. J Immunol. 2007 Dec 15;179(12):8500-8. doi: 10.4049/jimmunol.179.12.8500. J Immunol. 2007. PMID: 18056397
Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production.
Gomes RN, Figueiredo RT, Bozza FA, Pacheco P, Amâncio RT, Laranjeira AP, Castro-Faria-Neto HC, Bozza PT, Bozza MT. Gomes RN, et al. Among authors: pacheco p. Shock. 2006 Nov;26(5):457-63. doi: 10.1097/01.shk.0000228801.56223.92. Shock. 2006. PMID: 17047515
335 results