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Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice.
Bobermin LD, Sesterheim P, da Costa DS, Rezena E, Schmitz I, da Silva A, de Moraes ADM, Souza DO, Wyse AT, Leipnitz G, Netto CA, Quincozes-Santos A, Gonçalves CA. Bobermin LD, et al. Neurochem Res. 2024 Mar;49(3):732-743. doi: 10.1007/s11064-023-04073-w. Epub 2023 Dec 8. Neurochem Res. 2024. PMID: 38063948
In this regard, type I interferon (IFN) receptor signaling in astrocytes can regulate synaptic plasticity. Simvastatin is a cholesterol-lowering drug that has shown anti-inflammatory properties, but its effects on astrocytes, a main source of cholesterol for neurons …
In this regard, type I interferon (IFN) receptor signaling in astrocytes can regulate synaptic plasticity. Simvastatin is a cholesterol-lowe …