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Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.
Groß R, Reßin H, von Maltitz P, Albers D, Schneider L, Bley H, Hoffmann M, Cortese M, Gupta D, Deniz M, Choi JY, Jansen J, Preußer C, Seehafer K, Pöhlmann S, Voelker DR, Goffinet C, Pogge-von Strandmann E, Bunz U, Bartenschlager R, El Andaloussi S, Sparrer KMJ, Herker E, Becker S, Kirchhoff F, Münch J, Müller JA. Groß R, et al. Nat Microbiol. 2024 Apr;9(4):905-921. doi: 10.1038/s41564-024-01637-6. Epub 2024 Mar 25. Nat Microbiol. 2024. PMID: 38528146 Free PMC article.
Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization.
Lapuente D, Fuchs J, Willar J, Vieira Antão A, Eberlein V, Uhlig N, Issmail L, Schmidt A, Oltmanns F, Peter AS, Mueller-Schmucker S, Irrgang P, Fraedrich K, Cara A, Hoffmann M, Pöhlmann S, Ensser A, Pertl C, Willert T, Thirion C, Grunwald T, Überla K, Tenbusch M. Lapuente D, et al. Nat Commun. 2021 Nov 26;12(1):6871. doi: 10.1038/s41467-021-27063-4. Nat Commun. 2021. PMID: 34836955 Free PMC article.
The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency.
Arora P, Rocha C, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jäck HM, Cossmann A, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Cell Mol Immunol. 2021 Dec;18(12):2673-2675. doi: 10.1038/s41423-021-00779-5. Epub 2021 Oct 25. Cell Mol Immunol. 2021. PMID: 34697413 Free PMC article. No abstract available.
Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance.
Arora P, Kempf A, Nehlmeier I, Graichen L, Sidarovich A, Winkler MS, Schulz S, Jäck HM, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. Arora P, et al. Cell Mol Immunol. 2021 Nov;18(11):2557-2559. doi: 10.1038/s41423-021-00772-y. Epub 2021 Oct 11. Cell Mol Immunol. 2021. PMID: 34635807 Free PMC article. No abstract available.