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Uncoupling of Ca2+ sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia.
Taylor JL, Walsh KR, Mosneag IE, Danby TGE, Luka N, Chanda B, Schiessl I, Dunne RA, Hill-Eubanks D, Hennig GW, Allan SM, Nelson MT, Greenstein AS, Pritchard HAT. Taylor JL, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2307513120. doi: 10.1073/pnas.2307513120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549299 Free PMC article.
Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
Taylor JL, Pritchard HAT, Walsh KR, Strangward P, White C, Hill-Eubanks D, Alakrawi M, Hennig GW, Allan SM, Nelson MT, Greenstein AS. Taylor JL, et al. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204581119. doi: 10.1073/pnas.2204581119. Epub 2022 Jun 21. Proc Natl Acad Sci U S A. 2022. PMID: 35727988 Free PMC article.
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.
Jiang X, Eales JM, Scannali D, Nazgiewicz A, Prestes P, Maier M, Denniff M, Xu X, Saluja S, Cano-Gamez E, Wystrychowski W, Szulinska M, Antczak A, Byars S, Skrypnik D, Glyda M, Król R, Zywiec J, Zukowska-Szczechowska E, Burrell LM, Woolf AS, Greenstein A, Bogdanski P, Keavney B, Morris AP, Heagerty A, Williams B, Harrap SB, Trynka G, Samani NJ, Guzik TJ, Charchar FJ, Tomaszewski M. Jiang X, et al. Eur Heart J. 2020 Dec 21;41(48):4580-4588. doi: 10.1093/eurheartj/ehaa794. Eur Heart J. 2020. PMID: 33206176 Free PMC article.