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The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA. Larson ET, et al. J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11. J Mol Biol. 2010. PMID: 20070944 Free PMC article.
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.
Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WG. Verlinde CL, et al. Curr Top Med Chem. 2009;9(18):1678-87. doi: 10.2174/156802609790102383. Curr Top Med Chem. 2009. PMID: 19929835 Free PMC article. Review.
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA. Larson ET, et al. J Mol Biol. 2008 Sep 12;381(4):975-88. doi: 10.1016/j.jmb.2008.06.048. Epub 2008 Jun 24. J Mol Biol. 2008. PMID: 18602399 Free PMC article.