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Year Number of Results
2014 4
2015 9
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2017 8
2018 3
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2020 2
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2023 1
2024 0

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Page 1
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, Le Rouzic V, Eans SO, Simons CA, Hunkele A, Subrath J, Pan YX, Javitch JA, McLaughlin JP, Roth BL, Pasternak GW, Katritch V, Majumdar S. Uprety R, et al. Elife. 2021 Feb 8;10:e56519. doi: 10.7554/eLife.56519. Elife. 2021. PMID: 33555255 Free PMC article.
Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.
Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C. Schattauer SS, et al. J Biol Chem. 2019 Nov 8;294(45):16884-16896. doi: 10.1074/jbc.RA119.009592. Epub 2019 Oct 1. J Biol Chem. 2019. PMID: 31575661 Free PMC article.
Harnessing Ion-Binding Sites for GPCR Pharmacology.
Zarzycka B, Zaidi SA, Roth BL, Katritch V. Zarzycka B, et al. Pharmacol Rev. 2019 Oct;71(4):571-595. doi: 10.1124/pr.119.017863. Pharmacol Rev. 2019. PMID: 31551350 Free PMC article. Review.
35 results