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Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents.
Piska K, Koczurkiewicz P, Bucki A, Wójcik-Pszczoła K, Kołaczkowski M, Pękala E. Piska K, et al. Among authors: pekala e. Invest New Drugs. 2017 Jun;35(3):375-385. doi: 10.1007/s10637-017-0443-2. Epub 2017 Mar 10. Invest New Drugs. 2017. PMID: 28283780 Free PMC article. Review.
New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.
Chłoń-Rzepa G, Zagórska A, Bucki A, Kołaczkowski M, Pawłowski M, Satała G, Bojarski AJ, Partyka A, Wesołowska A, Pękala E, Słoczyńska K. Chłoń-Rzepa G, et al. Among authors: pekala e. Arch Pharm (Weinheim). 2015 Apr;348(4):242-53. doi: 10.1002/ardp.201500015. Epub 2015 Mar 13. Arch Pharm (Weinheim). 2015. PMID: 25773907
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Gunia-Krzyżak A, Żesławska E, Słoczyńska K, Koczurkiewicz P, Nitek W, Żelaszczyk D, Szkaradek N, Waszkielewicz AM, Pękala E, Marona H. Gunia-Krzyżak A, et al. Among authors: pekala e. Eur J Med Chem. 2016 Jan 1;107:26-37. doi: 10.1016/j.ejmech.2015.10.051. Epub 2015 Nov 2. Eur J Med Chem. 2016. PMID: 26560050
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.
Zagórska A, Bucki A, Kołaczkowski M, Siwek A, Głuch-Lutwin M, Starowicz G, Kazek G, Partyka A, Wesołowska A, Słoczyńska K, Pękala E, Pawłowski M. Zagórska A, et al. Among authors: pekala e. J Enzyme Inhib Med Chem. 2016;31(sup3):10-24. doi: 10.1080/14756366.2016.1198902. Epub 2016 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 27353547
Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition.
Wójcik-Pszczoła K, Hińcza K, Wnuk D, Kądziołka D, Koczurkiewicz P, Sanak M, Madeja Z, Pękala E, Michalik M. Wójcik-Pszczoła K, et al. Among authors: pekala e. Acta Biochim Pol. 2016;63(3):437-42. doi: 10.18388/abp.2016_1357. Epub 2016 Jul 30. Acta Biochim Pol. 2016. PMID: 27474406 Free article.
Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity.
Marcinkowska M, Kołaczkowski M, Kamiński K, Bucki A, Pawłowski M, Siwek A, Karcz T, Mordyl B, Starowicz G, Kubowicz P, Pękala E, Wesołowska A, Samochowiec J, Mierzejewski P, Bienkowski P. Marcinkowska M, et al. Among authors: pekala e. Eur J Med Chem. 2016 Nov 29;124:456-467. doi: 10.1016/j.ejmech.2016.08.059. Epub 2016 Aug 26. Eur J Med Chem. 2016. PMID: 27598234
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.
Rapacz A, Kamiński K, Obniska J, Koczurkiewicz P, Pękala E, Filipek B. Rapacz A, et al. Among authors: pekala e. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jun;390(6):567-579. doi: 10.1007/s00210-017-1358-3. Epub 2017 Feb 10. Naunyn Schmiedebergs Arch Pharmacol. 2017. PMID: 28188357 Free PMC article.
3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.
Marcinkowska M, Kołaczkowski M, Kamiński K, Bucki A, Pawłowski M, Siwek A, Karcz T, Starowicz G, Słoczyńska K, Pękala E, Wesołowska A, Samochowiec J, Mierzejewski P, Bienkowski P. Marcinkowska M, et al. Among authors: pekala e. ACS Chem Neurosci. 2017 Jun 21;8(6):1291-1298. doi: 10.1021/acschemneuro.6b00432. Epub 2017 Mar 1. ACS Chem Neurosci. 2017. PMID: 28211669
121 results