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Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
J Clin Invest. 2024.
PMID: 38618957
Free PMC article.
Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.
Keeley AB, Kopranovic A, Di Lorenzo V, Ábrányi-Balogh P, Jänsch N, Lai LN, Petri L, Orgován Z, Pölöske D, Orlova A, Németh AG, Desczyk C, Imre T, Bajusz D, Moriggl R, Meyer-Almes FJ, Keserü GM.
Keeley AB, et al. Among authors: poloske d.
J Med Chem. 2024 Jan 11;67(1):572-585. doi: 10.1021/acs.jmedchem.3c01779. Epub 2023 Dec 19.
J Med Chem. 2024.
PMID: 38113354
Free PMC article.
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High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
Garcha HK, Nawar N, Sorger H, Erdogan F, Aung MMK, Sedighi A, Manaswiyoungkul P, Seo HS, Schönefeldt S, Pölöske D, Dhe-Paganon S, Neubauer HA, Mustjoki SM, Herling M, de Araujo ED, Moriggl R, Gunning PT.
Garcha HK, et al. Among authors: poloske d.
Pharmaceuticals (Basel). 2022 Oct 26;15(11):1321. doi: 10.3390/ph15111321.
Pharmaceuticals (Basel). 2022.
PMID: 36355493
Free PMC article.
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Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma.
Sorger H, Dey S, Vieyra-Garcia PA, Pölöske D, Teufelberger AR, de Araujo ED, Sedighi A, Graf R, Spiegl B, Lazzeri I, Braun T, Garces de Los Fayos Alonso I, Schlederer M, Timelthaler G, Kodajova P, Pirker C, Surbek M, Machtinger M, Graier T, Perchthaler I, Pan Y, Fink-Puches R, Cerroni L, Ober J, Otte M, Albrecht JD, Tin G, Abdeldayem A, Manaswiyoungkul P, Olaoye OO, Metzelder ML, Orlova A, Berger W, Wobser M, Nicolay JP, André F, Nguyen VA, Neubauer HA, Fleck R, Merkel O, Herling M, Heitzer E, Gunning PT, Kenner L, Moriggl R, Wolf P.
Sorger H, et al. Among authors: poloske d.
EMBO Mol Med. 2022 Dec 7;14(12):e15200. doi: 10.15252/emmm.202115200. Epub 2022 Nov 7.
EMBO Mol Med. 2022.
PMID: 36341492
Free PMC article.
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Efficacy and Synergy of Small Molecule Inhibitors Targeting FLT3-ITD+ Acute Myeloid Leukemia.
Bregante J, Schönbichler A, Pölöske D, Degenfeld-Schonburg L, Monzó Contreras G, Hadzijusufovic E, de Araujo ED, Valent P, Moriggl R, Orlova A.
Bregante J, et al. Among authors: poloske d.
Cancers (Basel). 2021 Dec 8;13(24):6181. doi: 10.3390/cancers13246181.
Cancers (Basel). 2021.
PMID: 34944800
Free PMC article.
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AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes.
Matzinger M, Fischhuber K, Pölöske D, Mechtler K, Heiss EH.
Matzinger M, et al. Among authors: poloske d.
Redox Biol. 2020 Jan;29:101393. doi: 10.1016/j.redox.2019.101393. Epub 2019 Nov 27.
Redox Biol. 2020.
PMID: 31805502
Free PMC article.
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