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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenco AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz N, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings C, Rothenberg ME, Pöhlmann S, Whelan SP, O'Donoghue AJ, Craik CS, Janetka JW. Mahoney M, et al. Among authors: pohlmann s. bioRxiv [Preprint]. 2021 May 6:2021.05.06.442935. doi: 10.1101/2021.05.06.442935. bioRxiv. 2021. PMID: 34131661 Free PMC article. Updated. Preprint.
Thiol drugs decrease SARS-CoV-2 lung injury in vivo and disrupt SARS-CoV-2 spike complex binding to ACE2 in vitro.
Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Pillai S, Healy AM, Duff T, Oscarson S, Hoffmann M, Pöhlmann S, Simmons G, Fahy JV. Khanna K, et al. Among authors: pohlmann s. bioRxiv [Preprint]. 2021 Nov 11:2020.12.08.415505. doi: 10.1101/2020.12.08.415505. bioRxiv. 2021. PMID: 33330868 Free PMC article. Preprint.
A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants.
Metzdorf K, Jacobsen H, Kim Y, Teixeira Alves LG, Kulkarni U, Eschke K, Chaudhry MZ, Hoffmann M, Bertoglio F, Ruschig M, Hust M, Cokarić Brdovčak M, Materljan J, Šustić M, Krmpotić A, Jonjić S, Widera M, Ciesek S, Pöhlmann S, Landthaler M, Čičin-Šain L. Metzdorf K, et al. Among authors: pohlmann s. bioRxiv [Preprint]. 2024 Feb 15:2022.11.25.517953. doi: 10.1101/2022.11.25.517953. bioRxiv. 2024. PMID: 36482969 Free PMC article. Preprint.
A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants.
Chiyyeadu A, Asgedom G, Bruhn M, Rocha C, Schlegel TU, Neumann T, Galla M, Vollmer Barbosa P, Hoffmann M, Ehrhardt K, Ha TC, Morgan M, Schoeder CT, Pöhlmann S, Kalinke U, Schambach A. Chiyyeadu A, et al. Among authors: pohlmann s. Clin Immunol. 2024 Mar;260:109902. doi: 10.1016/j.clim.2024.109902. Epub 2024 Jan 11. Clin Immunol. 2024. PMID: 38218210 Free article.
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity.
Flury P, Breidenbach J, Krüger N, Voget R, Schäkel L, Si Y, Krasniqi V, Calistri S, Olfert M, Sylvester K, Rocha C, Ditzinger R, Rasch A, Pöhlmann S, Kronenberger T, Poso A, Rox K, Laufer SA, Müller CE, Gütschow M, Pillaiyar T. Flury P, et al. Among authors: pohlmann s. ACS Pharmacol Transl Sci. 2024 Jan 19;7(2):493-514. doi: 10.1021/acsptsci.3c00313. eCollection 2024 Feb 9. ACS Pharmacol Transl Sci. 2024. PMID: 38357286
Fast formation of anode-free Li-metal batteries by pulsed current.
Cicvarić K, Pohlmann S, Zhang B, Rahmanian F, Merker L, Gaberšček M, Stein HS. Cicvarić K, et al. Among authors: pohlmann s. Phys Chem Chem Phys. 2024 May 8. doi: 10.1039/d4cp00775a. Online ahead of print. Phys Chem Chem Phys. 2024. PMID: 38716609
315 results