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Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance.
Pósa V, Stefanelli A, Nunes JHB, Hager S, Mathuber M, May NV, Berger W, Keppler BK, Kowol CR, Enyedy ÉA, Heffeter P. Pósa V, et al. Cancers (Basel). 2022 Sep 14;14(18):4455. doi: 10.3390/cancers14184455. Cancers (Basel). 2022. PMID: 36139615 Free PMC article.
Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.
Bormio Nunes JH, Hager S, Mathuber M, Pósa V, Roller A, Enyedy ÉA, Stefanelli A, Berger W, Keppler BK, Heffeter P, Kowol CR. Bormio Nunes JH, et al. Among authors: posa v. J Med Chem. 2020 Nov 25;63(22):13719-13732. doi: 10.1021/acs.jmedchem.0c01277. Epub 2020 Nov 15. J Med Chem. 2020. PMID: 33190481 Free PMC article.
High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones.
Hager S, Pape VFS, Pósa V, Montsch B, Uhlik L, Szakács G, Tóth S, Jabronka N, Keppler BK, Kowol CR, Enyedy ÉA, Heffeter P. Hager S, et al. Among authors: posa v. Antioxid Redox Signal. 2020 Aug 20;33(6):395-414. doi: 10.1089/ars.2019.7854. Epub 2020 Jun 9. Antioxid Redox Signal. 2020. PMID: 32336116
Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential.
Côrte-Real L, Pósa V, Martins M, Colucas R, May NV, Fontrodona X, Romero I, Mendes F, Pinto Reis C, Gaspar MM, Pessoa JC, Enyedy ÉA, Correia I. Côrte-Real L, et al. Among authors: posa v. Inorg Chem. 2023 Jul 24;62(29):11466-11486. doi: 10.1021/acs.inorgchem.3c01066. Epub 2023 Jul 13. Inorg Chem. 2023. PMID: 37441730 Free PMC article.
Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes.
Ribeiro N, Bulut I, Sergi B, Pósa V, Spengler G, Sciortino G, André V, Ferreira LP, Biver T, Ugone V, Garribba E, Costa-Pessoa J, Enyedy ÉA, Acilan C, Correia I. Ribeiro N, et al. Among authors: posa v. Front Chem. 2023 Mar 21;11:1106349. doi: 10.3389/fchem.2023.1106349. eCollection 2023. Front Chem. 2023. PMID: 37025548 Free PMC article.
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