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NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.
Marín-Aguilar F, Lechuga-Vieco AV, Alcocer-Gómez E, Castejón-Vega B, Lucas J, Garrido C, Peralta-Garcia A, Pérez-Pulido AJ, Varela-López A, Quiles JL, Ryffel B, Flores I, Bullón P, Ruiz-Cabello J, Cordero MD. Marín-Aguilar F, et al. Aging Cell. 2020 Jan;19(1):e13050. doi: 10.1111/acel.13050. Epub 2019 Oct 18. Aging Cell. 2020. PMID: 31625260 Free PMC article.
Mutation in cytochrome b gene of mitochondrial DNA in a family with fibromyalgia is associated with NLRP3-inflammasome activation.
Cordero MD, Alcocer-Gómez E, Marín-Aguilar F, Rybkina T, Cotán D, Pérez-Pulido A, Alvarez-Suarez JM, Battino M, Sánchez-Alcazar JA, Carrión AM, Culic O, Navarro-Pando JM, Bullón P. Cordero MD, et al. J Med Genet. 2016 Feb;53(2):113-22. doi: 10.1136/jmedgenet-2015-103392. Epub 2015 Nov 13. J Med Genet. 2016. PMID: 26566881
Inhibition of the NLRP3 inflammasome prevents ovarian aging.
Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, Navarro-Villarán E, Condés-Hervás M, Mundi-Roldan M, Muntané J, Pérez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD. Navarro-Pando JM, et al. Sci Adv. 2021 Jan 1;7(1):eabc7409. doi: 10.1126/sciadv.abc7409. Print 2021 Jan. Sci Adv. 2021. PMID: 33523841 Free PMC article.
NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.
Marín-Aguilar F, Castejón-Vega B, Alcocer-Gómez E, Lendines-Cordero D, Cooper MA, de la Cruz P, Andújar-Pulido E, Pérez-Alegre M, Muntané J, Pérez-Pulido AJ, Ryffel B, Robertson AAB, Ruiz-Cabello J, Bullón P, Cordero MD. Marín-Aguilar F, et al. J Gerontol A Biol Sci Med Sci. 2020 Jul 13;75(8):1457-1464. doi: 10.1093/gerona/glz239. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31603987
Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment.
Bullón P, Castejón-Vega B, Román-Malo L, Jimenez-Guerrero MP, Cotán D, Forbes-Hernandez TY, Varela-López A, Pérez-Pulido AJ, Giampieri F, Quiles JL, Battino M, Sánchez-Alcázar JA, Cordero MD. Bullón P, et al. J Allergy Clin Immunol. 2018 Oct;142(4):1131-1143.e7. doi: 10.1016/j.jaci.2018.01.018. Epub 2018 Feb 2. J Allergy Clin Immunol. 2018. PMID: 29410039
L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation.
Castejón-Vega B, Rubio A, Pérez-Pulido AJ, Quiles JL, Lane JD, Fernández-Domínguez B, Cachón-González MB, Martín-Ruiz C, Sanz A, Cox TM, Alcocer-Gómez E, Cordero MD. Castejón-Vega B, et al. Among authors: perez pulido aj. Cells. 2021 Nov 11;10(11):3122. doi: 10.3390/cells10113122. Cells. 2021. PMID: 34831346 Free PMC article.
Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.
Álvarez-Córdoba M, Fernández Khoury A, Villanueva-Paz M, Gómez-Navarro C, Villalón-García I, Suárez-Rivero JM, Povea-Cabello S, de la Mata M, Cotán D, Talaverón-Rey M, Pérez-Pulido AJ, Salas JJ, Pérez-Villegas EM, Díaz-Quintana A, Armengol JA, Sánchez-Alcázar JA. Álvarez-Córdoba M, et al. Mol Neurobiol. 2019 May;56(5):3638-3656. doi: 10.1007/s12035-018-1333-0. Epub 2018 Sep 1. Mol Neurobiol. 2019. PMID: 30173408
46 results