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Back to the future: Rational maps for exploring acetylcholine receptor space and time.
Tessier CJG, Emlaw JR, Cao ZQ, Pérez-Areales FJ, Salameh JJ, Prinston JE, McNulty MS, daCosta CJB. Tessier CJG, et al. Among authors: perez areales fj. Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1522-1528. doi: 10.1016/j.bbapap.2017.08.006. Epub 2017 Aug 24. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28844740 Review.
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. Pérez-Areales FJ, et al. Eur J Med Chem. 2019 Oct 15;180:613-626. doi: 10.1016/j.ejmech.2019.07.051. Epub 2019 Jul 17. Eur J Med Chem. 2019. PMID: 31351393 Free article.
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Sola I, Artigas A, Taylor MC, Pérez-Areales FJ, Viayna E, Clos MV, Pérez B, Wright CW, Kelly JM, Muñoz-Torrero D. Sola I, et al. Among authors: perez areales fj. Bioorg Med Chem. 2016 Nov 1;24(21):5162-5171. doi: 10.1016/j.bmc.2016.08.036. Epub 2016 Aug 22. Bioorg Med Chem. 2016. PMID: 27591008 Free PMC article.
Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.
Pérez-Areales FJ, Di Pietro O, Espargaró A, Vallverdú-Queralt A, Galdeano C, Ragusa IM, Viayna E, Guillou C, Clos MV, Pérez B, Sabaté R, Lamuela-Raventós RM, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Bioorg Med Chem. 2014 Oct 1;22(19):5298-307. doi: 10.1016/j.bmc.2014.07.053. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25156301
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Pérez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaró A, Ginex T, Sabate R, Pérez B, Andrisano V, Puigoriol-Illamola D, Pallàs M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Muñoz-Torrero D. Pérez-Areales FJ, et al. J Med Chem. 2020 Sep 10;63(17):9360-9390. doi: 10.1021/acs.jmedchem.0c00528. Epub 2020 Aug 11. J Med Chem. 2020. PMID: 32706255
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