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Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Turcu AL, Companys-Alemany J, Phillips MB, Patel DS, Griñán-Ferré C, Loza MI, Brea JM, Pérez B, Soto D, Sureda FX, Kurnikova MG, Johnson JW, Pallàs M, Vázquez S. Turcu AL, et al. Among authors: perez b. Eur J Med Chem. 2022 Jun 5;236:114354. doi: 10.1016/j.ejmech.2022.114354. Epub 2022 Apr 8. Eur J Med Chem. 2022. PMID: 35453065 Free PMC article.
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Di Pietro O, Viayna E, Vicente-García E, Bartolini M, Ramón R, Juárez-Jiménez J, Clos MV, Pérez B, Andrisano V, Luque FJ, Lavilla R, Muñoz-Torrero D. Di Pietro O, et al. Among authors: perez b. Eur J Med Chem. 2014 Feb 12;73:141-52. doi: 10.1016/j.ejmech.2013.12.008. Epub 2013 Dec 18. Eur J Med Chem. 2014. PMID: 24389509 Free article.
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Viayna E, et al. Among authors: perez b. J Med Chem. 2014 Mar 27;57(6):2549-67. doi: 10.1021/jm401824w. Epub 2014 Mar 10. J Med Chem. 2014. PMID: 24568372 Free article.
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Di Pietro O, Pérez-Areales FJ, Juárez-Jiménez J, Espargaró A, Clos MV, Pérez B, Lavilla R, Sabaté R, Luque FJ, Muñoz-Torrero D. Di Pietro O, et al. Among authors: perez areales fj, perez b. Eur J Med Chem. 2014 Sep 12;84:107-17. doi: 10.1016/j.ejmech.2014.07.021. Epub 2014 Jul 7. Eur J Med Chem. 2014. PMID: 25016233
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Di Pietro O, Vicente-García E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Pérez B, Kelly JM, Lavilla R, Muñoz-Torrero D. Di Pietro O, et al. Among authors: perez b. Eur J Med Chem. 2015 Nov 13;105:120-37. doi: 10.1016/j.ejmech.2015.10.007. Epub 2015 Oct 19. Eur J Med Chem. 2015. PMID: 26479031 Free PMC article.
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Di Pietro O, Alencar N, Esteban G, Viayna E, Szałaj N, Vázquez J, Juárez-Jiménez J, Sola I, Pérez B, Solé M, Unzeta M, Muñoz-Torrero D, Luque FJ. Di Pietro O, et al. Among authors: perez b. Bioorg Med Chem. 2016 Oct 15;24(20):4835-4854. doi: 10.1016/j.bmc.2016.06.045. Epub 2016 Jun 28. Bioorg Med Chem. 2016. PMID: 27396685
Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.
Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: perez b. Future Med Chem. 2017 Jun;9(10):965-981. doi: 10.4155/fmc-2017-0049. Epub 2017 Jun 20. Future Med Chem. 2017. PMID: 28632395
Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice.
Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M. Griñán-Ferré C, et al. Among authors: perez b. Neurotherapeutics. 2019 Apr;16(2):416-431. doi: 10.1007/s13311-018-00681-5. Neurotherapeutics. 2019. PMID: 30460457 Free PMC article.
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Pérez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabate R, Sureda FX, Vázquez S, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: perez b. Eur J Med Chem. 2019 Oct 15;180:613-626. doi: 10.1016/j.ejmech.2019.07.051. Epub 2019 Jul 17. Eur J Med Chem. 2019. PMID: 31351393 Free article.
907 results