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Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents.
Bellver-Sanchis A, Singh Choudhary B, Companys-Alemany J, Sukanya, Ávila-López PA, Martínez Rodríguez AL, Brea Floriani JM, Malik R, Pallàs M, Pérez B, Griñán-Ferré C. Bellver-Sanchis A, et al. Among authors: perez b. ChemMedChem. 2022 Jul 5;17(13):e202200002. doi: 10.1002/cmdc.202200002. Epub 2022 May 19. ChemMedChem. 2022. PMID: 35413149 Free PMC article.
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabaté R, Juárez-Jiménez J, Pérez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Muñoz-Torrero D. Viayna E, et al. Among authors: perez b. J Med Chem. 2014 Mar 27;57(6):2549-67. doi: 10.1021/jm401824w. Epub 2014 Mar 10. J Med Chem. 2014. PMID: 24568372 Free article.
Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice.
Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M. Griñán-Ferré C, et al. Among authors: perez b. Neurotherapeutics. 2019 Apr;16(2):416-431. doi: 10.1007/s13311-018-00681-5. Neurotherapeutics. 2019. PMID: 30460457 Free PMC article.
Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer's Disease.
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Radan M, Djikic T, Nikolic K, Pallàs M, Callado LF, Escolano C. Abás S, et al. Among authors: perez lozano p, perez b. J Med Chem. 2020 Apr 9;63(7):3610-3633. doi: 10.1021/acs.jmedchem.9b02080. Epub 2020 Mar 19. J Med Chem. 2020. PMID: 32150414
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease.
Griñán-Ferré C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Pérez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vázquez S, Pallàs M, Galdeano C. Griñán-Ferré C, et al. Among authors: perez b. Neurotherapeutics. 2020 Oct;17(4):1825-1835. doi: 10.1007/s13311-020-00854-1. Neurotherapeutics. 2020. PMID: 32488482 Free PMC article.
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6.
Pérez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaró A, Ginex T, Sabate R, Pérez B, Andrisano V, Puigoriol-Illamola D, Pallàs M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Muñoz-Torrero D. Pérez-Areales FJ, et al. Among authors: perez b. J Med Chem. 2020 Sep 10;63(17):9360-9390. doi: 10.1021/acs.jmedchem.0c00528. Epub 2020 Aug 11. J Med Chem. 2020. PMID: 32706255
Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.
Rodriguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Pallàs M, Brocos-Mosquera I, Callado LF, Loza MI, Martínez AL, Brea J, Pérez B, Molins E, De Jonghe S, Daelemans D, Radan M, Djikic T, Nikolic K, Hernández-Hernández E, García-Fuster MJ, García-Sevilla JA, Escolano C. Rodriguez-Arévalo S, et al. Among authors: perez b. Eur J Med Chem. 2021 Oct 15;222:113540. doi: 10.1016/j.ejmech.2021.113540. Epub 2021 May 20. Eur J Med Chem. 2021. PMID: 34118720 Free article.
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallàs M, Luque FJ, Muñoz-Torrero D. Pont C, et al. Among authors: perez b. Eur J Med Chem. 2021 Dec 5;225:113779. doi: 10.1016/j.ejmech.2021.113779. Epub 2021 Aug 16. Eur J Med Chem. 2021. PMID: 34418785 Free article.
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
Codony S, Pont C, Griñán-Ferré C, Di Pede-Mattatelli A, Calvó-Tusell C, Feixas F, Osuna S, Jarné-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Pérez B, Bartra C, Sanfeliu C, Juárez-Jiménez J, Morisseau C, Hammock BD, Pallàs M, Vázquez S, Muñoz-Torrero D. Codony S, et al. Among authors: perez b. J Med Chem. 2022 Mar 24;65(6):4909-4925. doi: 10.1021/acs.jmedchem.1c02150. Epub 2022 Mar 10. J Med Chem. 2022. PMID: 35271276 Free PMC article.
907 results