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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.
Ren F, Aliper A, Chen J, Zhao H, Rao S, Kuppe C, Ozerov IV, Zhang M, Witte K, Kruse C, Aladinskiy V, Ivanenkov Y, Polykovskiy D, Fu Y, Babin E, Qiao J, Liang X, Mou Z, Wang H, Pun FW, Ayuso PT, Veviorskiy A, Song D, Liu S, Zhang B, Naumov V, Ding X, Kukharenko A, Izumchenko E, Zhavoronkov A. Ren F, et al. Among authors: ozerov iv. Nat Biotechnol. 2024 Mar 8. doi: 10.1038/s41587-024-02143-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38459338
AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor.
Ren F, Ding X, Zheng M, Korzinkin M, Cai X, Zhu W, Mantsyzov A, Aliper A, Aladinskiy V, Cao Z, Kong S, Long X, Man Liu BH, Liu Y, Naumov V, Shneyderman A, Ozerov IV, Wang J, Pun FW, Polykovskiy DA, Sun C, Levitt M, Aspuru-Guzik A, Zhavoronkov A. Ren F, et al. Among authors: ozerov iv. Chem Sci. 2023 Jan 10;14(6):1443-1452. doi: 10.1039/d2sc05709c. eCollection 2023 Feb 8. Chem Sci. 2023. PMID: 36794205 Free PMC article.
AI-powered therapeutic target discovery.
Pun FW, Ozerov IV, Zhavoronkov A. Pun FW, et al. Among authors: ozerov iv. Trends Pharmacol Sci. 2023 Sep;44(9):561-572. doi: 10.1016/j.tips.2023.06.010. Epub 2023 Jul 19. Trends Pharmacol Sci. 2023. PMID: 37479540 Free article. Review.
PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery.
Kamya P, Ozerov IV, Pun FW, Tretina K, Fokina T, Chen S, Naumov V, Long X, Lin S, Korzinkin M, Polykovskiy D, Aliper A, Ren F, Zhavoronkov A. Kamya P, et al. Among authors: ozerov iv. J Chem Inf Model. 2024 Feb 25. doi: 10.1021/acs.jcim.3c01619. Online ahead of print. J Chem Inf Model. 2024. PMID: 38404138
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
Pun FW, Leung GHD, Leung HW, Liu BHM, Long X, Ozerov IV, Wang J, Ren F, Aliper A, Izumchenko E, Moskalev A, de Magalhães JP, Zhavoronkov A. Pun FW, et al. Among authors: ozerov iv. Aging (Albany NY). 2022 Mar 29;14(6):2475-2506. doi: 10.18632/aging.203960. Epub 2022 Mar 29. Aging (Albany NY). 2022. PMID: 35347083 Free PMC article.
A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Pun FW, Leung GHD, Leung HW, Rice J, Schmauck-Medina T, Lautrup S, Long X, Liu BHM, Wong CW, Ozerov IV, Aliper A, Ren F, Rosenberg AJ, Agrawal N, Izumchenko E, Fang EF, Zhavoronkov A. Pun FW, et al. Among authors: ozerov iv. Aging Cell. 2023 Dec;22(12):e14017. doi: 10.1111/acel.14017. Epub 2023 Oct 27. Aging Cell. 2023. PMID: 37888486 Free PMC article.
Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform.
Olsen A, Harpaz Z, Ren C, Shneyderman A, Veviorskiy A, Dralkina M, Konnov S, Shcheglova O, Pun FW, Leung GHD, Leung HW, Ozerov IV, Aliper A, Korzinkin M, Zhavoronkov A. Olsen A, et al. Among authors: ozerov iv. Aging (Albany NY). 2023 Apr 26;15(8):2863-2876. doi: 10.18632/aging.204678. Epub 2023 Apr 26. Aging (Albany NY). 2023. PMID: 37100462 Free PMC article.
Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Pun FW, Liu BHM, Long X, Leung HW, Leung GHD, Mewborne QT, Gao J, Shneyderman A, Ozerov IV, Wang J, Ren F, Aliper A, Bischof E, Izumchenko E, Guan X, Zhang K, Lu B, Rothstein JD, Cudkowicz ME, Zhavoronkov A. Pun FW, et al. Among authors: ozerov iv. Front Aging Neurosci. 2022 Jun 28;14:914017. doi: 10.3389/fnagi.2022.914017. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35837482 Free PMC article.
39 results