Ozcan U - Search Results

1

FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity.

Herrema H, Guan D, Choi JW, Feng X, Salazar Hernandez MA, Faruk F, Auen T, Boudett E, Tao R, Chun H, Ozcan U. Herrema H, et al. Among authors: ozcan u. Cell Metab. 2022 Jul 5;34(7):1004-1022.e8. doi: 10.1016/j.cmet.2022.06.007. Cell Metab. 2022. PMID: 35793654 Free article.

2

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. Ozcan U, et al. Science. 2004 Oct 15;306(5695):457-61. doi: 10.1126/science.1103160. Science. 2004. PMID: 15486293

3

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS. Ozcan U, et al. Among authors: ozcan l. Science. 2006 Aug 25;313(5790):1137-40. doi: 10.1126/science.1128294. Science. 2006. PMID: 16931765 Free PMC article.

4

Endoplasmic reticulum stress plays a central role in development of leptin resistance.

Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U. Ozcan L, et al. Among authors: ozcan u. Cell Metab. 2009 Jan 7;9(1):35-51. doi: 10.1016/j.cmet.2008.12.004. Cell Metab. 2009. PMID: 19117545 Free article.

5

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation.

Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. Park SW, et al. Among authors: ozcan u. Nat Med. 2010 Apr;16(4):429-37. doi: 10.1038/nm.2099. Epub 2010 Mar 28. Nat Med. 2010. PMID: 20348926 Free PMC article.

6

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.

Park SW, Zhou Y, Lee J, Lee J, Ozcan U. Park SW, et al. Among authors: ozcan u. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19320-5. doi: 10.1073/pnas.1012044107. Epub 2010 Oct 25. Proc Natl Acad Sci U S A. 2010. PMID: 20974941 Free PMC article.

7

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.

Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Zhou Y, et al. Among authors: ozcan u. Nat Med. 2011 Mar;17(3):356-65. doi: 10.1038/nm.2293. Epub 2011 Feb 13. Nat Med. 2011. PMID: 21317886 Free PMC article.

8

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis.

Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. Lee J, et al. Among authors: ozcan u. Nat Med. 2011 Sep 4;17(10):1251-60. doi: 10.1038/nm.2449. Nat Med. 2011. PMID: 21892182 Free PMC article.

9

Potential for therapeutic manipulation of the UPR in disease.

Park SW, Ozcan U. Park SW, et al. Among authors: ozcan u. Semin Immunopathol. 2013 May;35(3):351-73. doi: 10.1007/s00281-013-0370-z. Epub 2013 Apr 10. Semin Immunopathol. 2013. PMID: 23572207 Free PMC article. Review.

10

Unfolded protein response signaling and metabolic diseases.

Lee J, Ozcan U. Lee J, et al. Among authors: ozcan u. J Biol Chem. 2014 Jan 17;289(3):1203-11. doi: 10.1074/jbc.R113.534743. Epub 2013 Dec 9. J Biol Chem. 2014. PMID: 24324257 Free PMC article. Review.

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