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Phosphodiesterases as therapeutic targets for Alzheimer's disease.
García-Osta A, Cuadrado-Tejedor M, García-Barroso C, Oyarzábal J, Franco R. García-Osta A, et al. Among authors: oyarzabal j. ACS Chem Neurosci. 2012 Nov 21;3(11):832-44. doi: 10.1021/cn3000907. Epub 2012 Oct 1. ACS Chem Neurosci. 2012. PMID: 23173065 Free PMC article. Review.
Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.
Sánchez-Arias JA, Rabal O, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, Ugarte A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J. Sánchez-Arias JA, et al. Among authors: oyarzabal j. ACS Chem Neurosci. 2017 Mar 15;8(3):638-661. doi: 10.1021/acschemneuro.6b00370. Epub 2016 Dec 27. ACS Chem Neurosci. 2017. PMID: 27936591
Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782. doi: 10.1021/acschemneuro.8b00648. Epub 2018 Dec 21. ACS Chem Neurosci. 2019. PMID: 30525452
Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles.
Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Tan H, Wu W, Xu M, Pineda-Lucena A, Garcia-Osta A, Oyarzabal J. Rabal O, et al. Among authors: oyarzabal j. ACS Chem Neurosci. 2019 Sep 18;10(9):4076-4101. doi: 10.1021/acschemneuro.9b00303. Epub 2019 Sep 4. ACS Chem Neurosci. 2019. PMID: 31441641
Phosphodiesterase inhibition in cognitive decline.
García-Barroso C, Ugarte A, Martínez M, Rico AJ, Lanciego JL, Franco R, Oyarzabal J, Cuadrado-Tejedor M, García-Osta A. García-Barroso C, et al. Among authors: oyarzabal j. J Alzheimers Dis. 2014;42 Suppl 4:S561-73. doi: 10.3233/JAD-141341. J Alzheimers Dis. 2014. PMID: 25125473 Review.
Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease.
Ugarte A, Gil-Bea F, García-Barroso C, Cedazo-Minguez Á, Ramírez MJ, Franco R, García-Osta A, Oyarzabal J, Cuadrado-Tejedor M. Ugarte A, et al. Among authors: oyarzabal j. Neuropathol Appl Neurobiol. 2015 Jun;41(4):471-82. doi: 10.1111/nan.12203. Neuropathol Appl Neurobiol. 2015. PMID: 25488891
Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease.
Cuadrado-Tejedor M, Garcia-Barroso C, Sanzhez-Arias J, Mederos S, Rabal O, Ugarte A, Franco R, Pascual-Lucas M, Segura V, Perea G, Oyarzabal J, Garcia-Osta A. Cuadrado-Tejedor M, et al. Among authors: oyarzabal j. Clin Epigenetics. 2015 Oct 8;7:108. doi: 10.1186/s13148-015-0142-9. eCollection 2015. Clin Epigenetics. 2015. PMID: 26457123 Free PMC article.
A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.
Cuadrado-Tejedor M, Garcia-Barroso C, Sánchez-Arias JA, Rabal O, Pérez-González M, Mederos S, Ugarte A, Franco R, Segura V, Perea G, Oyarzabal J, Garcia-Osta A. Cuadrado-Tejedor M, et al. Among authors: oyarzabal j. Neuropsychopharmacology. 2017 Jan;42(2):524-539. doi: 10.1038/npp.2016.163. Epub 2016 Aug 23. Neuropsychopharmacology. 2017. PMID: 27550730 Free PMC article.
101 results