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Targeting GLP-1 receptor trafficking to improve agonist efficacy.
Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen BM, Scott R, Goldin R, Angkathunyakul N, Corrêa IR Jr, Bosco D, Johnson PR, Piemonti L, Marchetti P, Shapiro AMJ, Cochran BJ, Hanyaloglu AC, Inoue A, Tan T, Rutter GA, Tomas A, Bloom SR. Jones B, et al. Among authors: owen bm. Nat Commun. 2018 Apr 23;9(1):1602. doi: 10.1038/s41467-018-03941-2. Nat Commun. 2018. PMID: 29686402 Free PMC article.
Steroidogenic control of liver metabolism through a nuclear receptor-network.
Milona A, Massafra V, Vos H, Naik J, Artigas N, Paterson HAB, Bijsmans ITGW, Willemsen ECL, Ramos Pittol JM, Miguel-Aliaga I, Bosma P, Burgering BMT, Williamson C, Vernia S, Dhillo WS, van Mil SWC, Owen BM. Milona A, et al. Among authors: owen bm. Mol Metab. 2019 Dec;30:221-229. doi: 10.1016/j.molmet.2019.09.007. Epub 2019 Sep 30. Mol Metab. 2019. PMID: 31767173 Free PMC article.
Hypoaminoacidemia underpins glucagon-mediated energy expenditure and weight loss.
Hope DCD, Hinds CE, Lopes T, Vincent ML, Shrewsbury JV, Yu ATC, Davies I, Scott R, Jones B, Murphy KG, Minnion JS, Sardini A, Carling D, Lutz TA, Bloom SR, Tan TMM, Owen BM. Hope DCD, et al. Among authors: owen bm. Cell Rep Med. 2022 Nov 15;3(11):100810. doi: 10.1016/j.xcrm.2022.100810. Cell Rep Med. 2022. PMID: 36384093 Free PMC article.
Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis.
Suba K, Patel Y, Martin-Alonso A, Hansen B, Xu X, Roberts A, Norton M, Chung P, Shrewsbury J, Kwok R, Kalogianni V, Cheng S, Liu X, Kalyviotis K, Rutter GA, Jones B, Minnion J, Owen BM, Pantazis P, Distaso W, Drucker DJ, Tan TM, Bloom SR, Murphy KG, Salem V. Suba K, et al. Among authors: owen bm. Mol Metab. 2024 Apr 26:101947. doi: 10.1016/j.molmet.2024.101947. Online ahead of print. Mol Metab. 2024. PMID: 38677509 Free article.
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.
Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA. Talukdar S, et al. Among authors: owen bm. Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001. Cell Metab. 2016. PMID: 26959184 Free article. Clinical Trial.
Metabolic roles of endocrine fibroblast growth factors.
Fernandes-Freitas I, Owen BM. Fernandes-Freitas I, et al. Among authors: owen bm. Curr Opin Pharmacol. 2015 Dec;25:30-5. doi: 10.1016/j.coph.2015.09.014. Epub 2015 Oct 24. Curr Opin Pharmacol. 2015. PMID: 26531325 Review.
41 results