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The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
Hörbelt T, Knebel B, Fahlbusch P, Barbosa D, de Wiza DH, Van de Velde F, Van Nieuwenhove Y, Lapauw B, Thoresen GH, Al-Hasani H, Müller-Wieland D, Ouwens DM, Kotzka J. Hörbelt T, et al. Among authors: ouwens dm. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2671-2684. doi: 10.1016/j.bbadis.2019.07.008. Epub 2019 Jul 20. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31336149 Free article.
The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.
Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM. Hörbelt T, et al. Among authors: ouwens dm. Diabetologia. 2018 Sep;61(9):2054-2065. doi: 10.1007/s00125-018-4636-9. Epub 2018 May 12. Diabetologia. 2018. PMID: 29754289
Secretome profiling of primary human skeletal muscle cells.
Hartwig S, Raschke S, Knebel B, Scheler M, Irmler M, Passlack W, Muller S, Hanisch FG, Franz T, Li X, Dicken HD, Eckardt K, Beckers J, de Angelis MH, Weigert C, Häring HU, Al-Hasani H, Ouwens DM, Eckel J, Kotzka J, Lehr S. Hartwig S, et al. Among authors: ouwens dm. Biochim Biophys Acta. 2014 May;1844(5):1011-7. doi: 10.1016/j.bbapap.2013.08.004. Epub 2013 Aug 27. Biochim Biophys Acta. 2014. PMID: 23994228
Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6.
Hartwig S, Goeddeke S, Poschmann G, Dicken HD, Jacob S, Nitzgen U, Passlack W, Stühler K, Ouwens DM, Al-Hasani H, Knebel B, Kotzka J, Lehr S. Hartwig S, et al. Among authors: ouwens dm. Arch Physiol Biochem. 2014 Dec;120(5):208-15. doi: 10.3109/13813455.2014.970197. Epub 2014 Oct 16. Arch Physiol Biochem. 2014. PMID: 25319219
Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity.
Bekaert M, Ouwens DM, Hörbelt T, Van de Velde F, Fahlbusch P, Herzfeld de Wiza D, Van Nieuwenhove Y, Calders P, Praet M, Hoorens A, Geerts A, Verhelst X, Kaufman JM, Lapauw B. Bekaert M, et al. Among authors: ouwens dm. Obesity (Silver Spring). 2016 Dec;24(12):2544-2552. doi: 10.1002/oby.21674. Epub 2016 Oct 21. Obesity (Silver Spring). 2016. PMID: 27768254 Free article.
CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.
Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J. Göddeke S, et al. Among authors: ouwens dm. Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21. Int J Obes (Lond). 2018. PMID: 29467502
Impact of hyperinsulinemia and hyperglycemia on valvular interstitial cells - A link between aortic heart valve degeneration and type 2 diabetes.
Selig JI, Ouwens DM, Raschke S, Thoresen GH, Fischer JW, Lichtenberg A, Akhyari P, Barth M. Selig JI, et al. Among authors: ouwens dm. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2526-2537. doi: 10.1016/j.bbadis.2019.05.019. Epub 2019 May 30. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31152868 Free article.
113 results